Correlation Between Angiotensin Converting Enzyme I/D Polymorphism and Erectile Dysfunction: An Appraisal

Angiotensin converting enzyme (ACE) is the major regulator of mineralocorticoid synthesis. ACE is mentioned for its responsibility for several vascular diseases. Considering the close relationship in the pathophysiology of these diseases and erectile dysfunction, the analysis of the association of genotypes in erectile dysfunction stands to reason. Here, the author performs a summative analysis on the recent previous reports on the ACE polymorphism and its correlation to erectile dysfunction. The meta-analysis was performed in order to assess the correlation between the pattern of ACE polymorphism and its correlation to erectile dysfunction. From available three case-control studies, 408 patients and 365 controls are evaluated. The overall frequencies of DD genotype for the patients and controls 28.2 are 21.6%, respectively. The overall frequency in the patients is slightly non-significant, higher ( 1.3 times) than controls (p >0.05). According to this study, 59.3% of subjects with DD genotype have erectile dysfunction while 50.6% of subjects without DD genotype have cardiovascular disease. From overall risk estimation, the subjects with DD genotype have 1.2 times higher risk to have erectile dysfunction.