Osteoimmunology in rheumatic diseases

被引：0
作者：
Georg Schett
机构：
[1] University of Erlangen-Nuremberg,Department of Internal Medicine 3 and Institute for Clinical Immunology
来源：
Arthritis Research & Therapy | / 11卷
关键词：
Rheumatoid Arthritis; Bone Formation; Rheumatoid Arthritis Patient; Ankylose Spondylitis; Rheumatic Disease;
D O I：
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摘要：
This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed significantly to the understanding of joint destruction in rheumatoid arthritis and other forms of arthropathies. In particular, the molecular regulation of osteoclast formation and its control by proinflammatory cytokines have helped investigators to understand the mechanisms of bone erosion in rheumatic diseases. Osteoimmunology has also allowed an improvement in our knowledge of the structure-sparing effects of antirheumatic drug therapy. Moreover, recent advances in the understanding of the molecular regulation of osteophyte formation are based on the characterization of the regulation of bone formation by inflammation. This review highlights the key insights into the regulation of bone destruction and formation in arthritis. Moreover, concepts of how bone influences the immune system are discussed.
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