Solvatochromism and Preferential Solvation of Deferiprone in Some Water–Organic Mixed Solvents

The molar transition energy (ET) values for deferiprone as a solvatochromic probe were measured in different aqueous binary mixtures of methanol, ethanol, 2-propanol, and 1-propanol (as HBD solvents) and acetonitrile and dioxane (as HBA solvents). Plots of ET as a function of mole fraction of the organic solvents were obtained and the data were analyzed to investigate preferential solvation of the drug in terms of both solute–solvent and solvent–solvent interactions. Also, the local mole fraction of each solvent composition was calculated in the cybotactic region of the probe. The molar transition energy of deferiprone in different binary mixtures was also analyzed in terms of Kamlet, Abboud, and Taft parameters. Dual and multiparameter correlation showed better results in HBD and HBA solvents, respectively.