Nothing in cancer makes sense except…

被引：0
作者：
Mel Greaves
机构：
[1] Centre for Evolution and Cancer,
[2] The Institute of Cancer Research,undefined
[3] Brookes Lawley Building,undefined
来源：
BMC Biology | / 16卷
关键词：
Cancer Clones; Dormant Cancer Stem Cells; Cancer Clonal Evolution; ABL Kinase Mutations; Natural Plant Toxins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its extensive diversity and therapeutic resilience, highlighting the need for more innovative approaches to control.
引用
收藏
相关论文
共 452 条
  • [1] Nesse RM(2008)The great opportunity: evolutionary applications to medicine and public health Evol Applications 1 28-48
  • [2] Stearns SC(2015)Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms Nat Rev Genet 16 459-471
  • [3] Hughes D(2003)Evolutionary biology in the medical school curriculum Bioscience 53 585-587
  • [4] Andersson DI(2006)Infection, immune responses and the aetiology of childhood leukaemia Nat Rev Cancer 6 193-203
  • [5] Nesse RM(2012)Clonal evolution in cancer Nature 481 306-313
  • [6] Schiffman JD(2015)Biological and therapeutic impact of intratumor heterogeneity in cancer evolution Cancer Cell 27 15-26
  • [7] Greaves M(2013)The implications of clonal genome evolution for cancer medicine N Engl J Med 368 842-851
  • [8] Greaves M(2015)Evolutionary determinants of cancer Cancer Discov 5 806-820
  • [9] Maley CC(2013)Punctuated evolution of prostate cancer genomes Cell 153 666-677
  • [10] McGranahan N(2014)Does everyone develop covert cancer? Nat Rev Cancer 14 209-210
12345678910