Micropipette aspiration of an inflated fluid-filled spherical membrane

被引：0
作者：
Touqeer Sohail
Tian Tang
Ben Nadler
机构：
[1] University of Alberta,Department of Mechanical Engineering
[2] University of Victoria,Department of Mechanical Engineering
来源：
Zeitschrift für angewandte Mathematik und Physik | 2012年 / 63卷
关键词：
Primary 74K15; Secondary 74S99; Micropipette; Spherical membrane; Aspirated length; Critical suction pressure; Cell mechanics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The micropipette technique has been widely used to determine the mechanical response of living cells. Cell is a complex structure and has highly nonlinear behavior when aspirated by the micropipette. Different models exist in the literature to determine the physical properties of the cells from the micropipette aspiration. In this work, we model the cell’s response during micropipette aspiration using continuum nonlinear membrane theory. The peripheral surface of the cell is modeled as a nonlinear membrane. The membrane is homogenous, isotropic, and of hyper-elastic material. The cytoplasm of the cell is modeled as an incompressible fluid. Our results show good agreement with the experiments reported in the literature.
引用
收藏
页码：737 / 757
页数：20
相关论文
共 89 条
  • [1] Yeung A.(1989)Cortical shell-liquid core model for passive flow of liquid-like spherical cells into micropipets Biophys. J. 56 139-149
  • [2] Evans E.(1982)Influence of physiochemical factors on rheology of human neutrophils Biophys. J. 39 101-106
  • [3] Sung K.(2002)An axisymmetric boundary integral model for assessing elastic cell properties in the micropipette aspiration contact problem ASME J. Biomech. Eng. 124 586-595
  • [4] Schmid-Schonbein G.(1981)Passive mechanical properties of human leukocytes Biophys. J. 36 243-256
  • [5] Skalak R.(1988)Leukocyte relaxation properties Biophys. J. 54 331-336
  • [6] Schuessler G.(1984)Passive material behavior of granulocyte based on large deformation and recovery after deformation tests Blood 64 1028-1035
  • [7] Usami S.(1990)Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties ASME J. Biomech. Eng. 112 263-268
  • [8] Chien S.(1999)Alterations in the young’s modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage J. Biomech. 32 119-127
  • [9] Haider M.(2000)Micropipette aspiration of living cells J. Biomech. 33 15-22
  • [10] Guilak F.(2001)Aspiration of human neutrophils: Effects of shear thinning and cortical dissipation Biophys. J. 81 3166-3177
123456789