A Human PBPK/PD Model to Assess Arsenic Exposure Risk Through Farmed Tilapia Consumption

被引：0
作者：
M.-P. Ling
C.-M. Liao
机构：
[1] China Medical University,Department of Health Risk Management
[2] National Taiwan University,Department of Bioenvironmental Systems Engineering
来源：
Bulletin of Environmental Contamination and Toxicology | 2009年 / 83卷
关键词：
Arsenic; PBPK/PD; Risk analysis; Consumption advice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The purpose of this study was to develop a biologically based risk assessment model for human health through consumption of arsenic (As) contaminated farmed tilapia (Oreochromis mossambicus) from blackfoot disease (BFD)-endemic area in Taiwan for estimating the consumption advice. We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human. Risk analysis indicates that consumption of farmed tilapia poses no significant threat from As-induced lung and bladder cancers. The predicted risk-based median consumption advice was no more than 5–17 meals month−1 (or 2–6 g day−1).
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页码：108 / 114
页数：6
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