Recent advances of the regulation roles of MicroRNA in glioblastoma

被引：0
作者：
Chengrui Yan
Xiangyi Kong
Shun Gong
Fengrui Liu
Yuanli Zhao
机构：
[1] Peking University International Hospital,Department of Neurosurgery
[2] Peking University Health Science Center,Department of Breast Surgical Oncology
[3] Peking University,Cambridge Breast Unit, Cambridge Biomedical Campus
[4] National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Breast Surgery Unit
[5] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Neurosurgery
[6] Addenbrooke’s Hospital,College of Literature, Science, and the Arts
[7] Cambridge University Hospitals NHS Foundation Trust,undefined
[8] University of Cambridge,undefined
[9] The Royal Marsden Hospital,undefined
[10] The Royal Marsden NHS Foundation Trust,undefined
[11] General Hospital of Northern Theater Command,undefined
[12] PLA Institute of Neurology,undefined
[13] University of Michigan,undefined
来源：
International Journal of Clinical Oncology | 2020年 / 25卷
关键词：
Glioblastoma; MicroRNA; Area under curve; Prognostic model; Temozolomide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glioblastoma (GBM) is one of the most malignant neural tumors, and patients with GBM often die soon after the onset. The pathogenesis of GBM is very complicated, and there is no effective treatment for GBM. The current research results show that a variety of microRNA (miRNA) are involved in the regulation of GBM occurrence and development through specific signal pathways. Meanwhile, as a non-invasive biological indicator, there is an important clinical value of miRNA in the diagnosis and prognosis of GBM. The research of targeted miRNA treatment for GBM is still in the cell and animal model stage, although the basic research shows a good result, there is still a certain distance to the clinical application.
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页码：1215 / 1222
页数：7
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