Genomic profiling in oncology clinical practice

被引：0
作者：
N. Rodríguez
D. Viñal
J. Rodríguez-Cobos
J. De Castro
G. Domínguez
机构：
[1] Catedra UAM-Medicina de Innovación,Department of Medical Oncology, Hospital Universitario La Paz
[2] Hospital Universitario La Paz,Department of Medical Oncology
[3] Instituto de Investigaciones Biomedicas “Alberto Sols”,Departamento de Bioquimica
[4] CSIC-UAM,undefined
来源：
Clinical and Translational Oncology | 2020年 / 22卷
关键词：
Genomic profiling; Next-generation sequencing; Sanger sequencing; Liquid biopsy; Hereditary cancer syndromes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The development of high-throughput technologies such as next-generation sequencing for DNA sequencing together with the decrease in their cost has led to the progressive introduction of genomic profiling in our daily practice in oncology. Nowadays, genomic profiling is part of genetic counseling, cancer diagnosis, molecular characterization, and as a biomarker of prognosis and response to treatment. Furthermore, germline or somatic genomic characterization of the tumor may provide new treatment opportunities for patients with cancer. In this review, we will summarize the clinical applications and limitations of genomic profiling in oncology clinical practice, focusing on next-generation sequencing.
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页码：1430 / 1439
页数：9
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