Cancer risks and long-term community-level exposure to pentachlorophenol in contaminated areas, China

被引:0
|
作者
Pan Cheng
Qinghe Zhang
Xiaomei Shan
Denghui Shen
Bingshuang Wang
Zhenhai Tang
Yu Jin
Chi Zhang
Fen Huang
机构
[1] Anhui Medical University,Department of Epidemiology and Biostatistics, School of Public Health
[2] Wuhu Hospital of Traditional Chinese Medicine,Department of Occupational and Environmental Health, School of Public Health
[3] Physical and Chemical Laboratory of Anhui Provincial Center for Disease Control and Prevention,undefined
[4] Anhui Medical University,undefined
来源
Environmental Science and Pollution Research | 2015年 / 22卷
关键词
Pentachlorophenol; Cancer risk; General population; Community-level; Ecological design; Drinking water;
D O I
暂无
中图分类号
学科分类号
摘要
Widespread use of pentachlorophenol (PCP) in schistosomiasis endemic areas had led to ubiquitous exposure to PCP and its residues. Numerous studies had revealed that occupational PCP exposure probably increased risk of cancers, but whether long-term community-level exposure to PCP generates the similarly carcinogenic effect, seldom studies focused on it. This study was to explore the cancer risks of long-term community-level PCP exposure from drinking water in a Chinese general population. Incident (2009–2012) cancer records were identified by local government national registry. And PCP concentration of raw drinking water samples in each district was measured by GC-MS/MS analysis for further division of three PCP exposure categories by interquartile range (high vs. medium vs. low). Internal comparisons were performed, and standard rate ratio was calculated to describe the relationship between PCP exposure and cancer risks by using low-exposure group as the reference group. PCP was detected in all 27 raw drinking water samples ranging from 11.21 to 684.00 ng/L. A total of 6,750 cases (4,409 male and 2,341 female cases) were identified, and age-standardized rate (world) was 154.95 per 100,000 person-years. The cancer incidence for the high-exposure group was remarkably high. Internal comparisons indicated that high PCP exposure might be positively associated with high cancer risks in the community population, particularly for leukemia (SRR = 5.93, 95 % CI = 5.24–6.71), maligant lymphoma (SRR = 2.27, 95 % CI = 2.10–2.54), and esophageal cancer (SRR = 2.42, 95 % CI = 2.35–2.50). Long-term community-level exposure to PCP was probably associated with hemolymph neoplasm, neurologic tumors, and digestive system neoplasm.
引用
收藏
页码:1309 / 1317
页数:8
相关论文
共 50 条
  • [41] Effects of long-term low-level radiation exposure after the Chernobyl catastrophe on immunoglobulins in children residing in contaminated areas: prospective and cross-sectional studies
    McMahon, Daria M.
    Vdovenko, Vitaliy Y.
    Karmaus, Wilfried
    Kondrashova, Valentina
    Svendsen, Erik
    Litvinetz, Oksana M.
    Stepanova, Yevgenia I.
    ENVIRONMENTAL HEALTH, 2014, 13
  • [42] Effects of long-term low-level radiation exposure after the Chernobyl catastrophe on immunoglobulins in children residing in contaminated areas: prospective and cross-sectional studies
    Daria M McMahon
    Vitaliy Y Vdovenko
    Wilfried Karmaus
    Valentina Kondrashova
    Erik Svendsen
    Oksana M Litvinetz
    Yevgenia I Stepanova
    Environmental Health, 13
  • [43] Long-term pesticide exposure and the risk of testicular cancer
    Giannandrea, Fabrizio
    OCCUPATIONAL MEDICINE-OXFORD, 2012, 62 (04): : 308 - 309
  • [44] Preventive role of community-level social capital in the need for long-term care and impairment in instrumental activities of daily living: a multilevel analysis
    Matsuura, Hitomi
    Hatono, Yoko
    Saito, Isao
    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 2023, 28
  • [45] Effect of long-term exposure to fluoride in drinking water on risks of bone fractures
    Li, YM
    Liang, CK
    Slemenda, CW
    Ji, RD
    Sun, SZ
    Cao, JX
    Emsley, CL
    Ma, F
    Wu, YP
    Ying, P
    Zhang, Y
    Gao, SJ
    Zhang, W
    Katz, BP
    Niu, SR
    Cao, SR
    Johnston, CC
    JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (05) : 932 - 939
  • [46] Modelling the behavior of pesticide residues in tomatoes and their associated long-term exposure risks
    Hlihor, Raluca-Maria
    Pogacean, Manuela Olga
    Rosca, Mihaela
    Cozma, Petronela
    Gavrilescu, Maria
    JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2019, 233 : 523 - 529
  • [47] Root surface areas in long-term survivors of childhood cancer
    Duggal, MS
    ORAL ONCOLOGY, 2003, 39 (02): : 178 - 183
  • [48] An Inter-disciplinary Approach to Evaluate Human Health Risks Due to Long-Term Exposure to Contaminated Groundwater Near a Chemical Complex
    Marina M. S. Cabral Pinto
    Carlos M. Ordens
    M. Teresa Condesso de Melo
    Manuela Inácio
    Agostinho Almeida
    Edgar Pinto
    Eduardo A. Ferreira da Silva
    Exposure and Health, 2020, 12 : 199 - 214
  • [49] An Inter-disciplinary Approach to Evaluate Human Health Risks Due to Long-Term Exposure to Contaminated Groundwater Near a Chemical Complex
    Cabral Pinto, Marina M. S.
    Ordens, Carlos M.
    Condesso de Melo, M. Teresa
    Inacio, Manuela
    Almeida, Agostinho
    Pinto, Edgar
    Ferreira da Silva, Eduardo A.
    EXPOSURE AND HEALTH, 2020, 12 (02) : 199 - 214
  • [50] Long-term effects of lifetime trauma exposure in a rural community sample
    Handley, Tonelle E.
    Kelly, Brian J.
    Lewin, Terry J.
    Coleman, Clare
    Stain, Helen J.
    Weaver, Natasha
    Inder, Kerry J.
    BMC PUBLIC HEALTH, 2015, 15