Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: A case report

被引：3

作者：

Navinan M.R. ^{[1
]}

Liyanage I. ^{[1
]}

Herath S. ^{[1
]}

Yudhishdran J. ^{[1
]}

Shivanthan C. ^{[1
]}

Beneragama D. ^{[2
]}

Kulatunga A. ^{[1
]}

机构：

[1] National Hospital of Sri Lanka, Colombo

[2] Department of Pathology, Faculty of Medicine, University of Sri Jayawardenepura, Colombo

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Inflammatory myofibroblastic tumour; Methotrexate; Para-nasal sinuses; Prednisolone;

D O I：

10.1186/s13104-015-0993-3

中图分类号：

学科分类号：

摘要：

Background: Inflammatory myofibroblastic tumour is a rare neoplasm with a potential to behave in a malignant manner. It can occur anywhere in the body, however involvement of the head, especially the para-nasal sinuses is rare. Case presentation: A 33-year-old South Asian male presented with coryzal symptoms including a persistent cough with an asymmetrical swelling of the left side of the face. Imaging revealed a mass lesion involving the para-nasal sinuses eroding into the orbit. Histology and the clinical picture were compatible with inflammatory myofibroblastic tumour. As curative excision of the tumour was not feasible, medical management was offered. Despite early features of remission to glucocorticoids, tapering resulted in recurrence. Hence combination therapy with glucocorticoids and methotrexate was commenced with dramatic reduction of tumour burden and the patient has been in remission to date. Conclusion: Inflammatory myofibroblastic tumour has the potential to behave in a malignant manner. Medical management with chemotherapy, glucocorticoids and non-steroidal anti-inflammatory drugs though effective, do not have a uniform response pattern. Surgically unresectable inflammatory myofibroblastic tumour above neck should be treated aggressively with combination regimens. Combination of prednisolone with methotrexate has been shown to have good outcome. © 2015 Navinan et al.

引用

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