Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics

被引：0
作者：
O. Gauthier
J.-M. Bouler
E. Aguado
R. Z. Legeros
P. Pilet
G. Daculsi
机构：
[1] Laboratoire de Chirurgie,Ecole Nationale Ve´te´rinaire de Nantes, Route de Gachet
[2] New York University,Faculte´ de Chirurgie Dentaire
[3] College of Dentistry,undefined
[4] Centre de Recherche sur les Mate´riaux d'lnte´re^t Biologique – UPRES EA 2159,undefined
来源：
Journal of Materials Science: Materials in Medicine | 1999年 / 10卷
关键词：
Apatite; Scan Electron Microscopy Observation; Biphasic Calcium Phosphate; Form Bone Rate; Calcium Oxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two different preparations of biphasic calcium phosphate (BCP) were characterized in vitro: BCP1 from a mechanical mixture of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) powders, and BCP2 from calcination of a calcium-deficient apatite (CDA). The structural, physicochemical and mechanical parameters of these two preparations were investigated, and two different macroporous BCP1 (MBCP1) and BCP2 MBCP2) implants were manufactured and implanted in rabbit bone for in vivo bioactivity studies. Scanning electron microscopy observations showed that MBCP1 implants had a significantly higher degradation rate (P<0.0001) than MBCP2 implants. This was probably caused by the presence of calcium oxide impurities in BCP1 and the more intimate mixture and stable ultrastructure of BCP2. No significant difference about the newly formed bone rate in these two BCP preparations was observed. Very slight variations in sintering conditions appeared to influence the biodegradation behavior of the two MBCP implants despite their identical HA/β-TCP ratios and similar porosity. Precise and complete in vitro characterization enabled us to understand and predict in vivo degradation behavior. © 1999 Kluwer Academic Publishers
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页码：199 / 204
页数：5
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