Cardiovascular disease: much more aggressive in patients with type 2 diabetes.

被引：26
作者：
Chiquette E. [1 ]
Chilton R. [1 ]
机构：
[1] University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, 78284-7872, TX
来源：
Current Atherosclerosis Reports | 2002年 / 4卷 / 2期
关键词：
Coronary Artery Bypass Graft; Pravastatin; United Kingdom Prospective Diabetes Study; Left Internal Mammary Artery; Silent Ischemia;
D O I：
10.1007/s11883-002-0037-z
中图分类号：
学科分类号：
摘要：
It is estimated that 80% of individuals with type 2 diabetes die of coronary heart disease. Several factors have been found to contribute to the accelerated atherosclerosis present in diabetic patients. These include hyperglycemia-induced endothelial cell dysfunction, impaired fibrinolysis, increased platelet aggregation, and dysfunctional arterial remodeling. The evidence supports that a healthy lifestyle, statin drugs, angiotensin-converting enzyme inhibitors, and aspirin can modify these factors and slow the atherosclerosis process observed in type 2 diabetes. Because of the high prevalence of cardiovascular disease in people with type 2 diabetes, early cardiac testing is indicated. The optimal strategy for coronary revascularization in diabetic patients remains controversial and is discussed in detail in this review.
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页码：134 / 142
页数：8
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