Penile change following radical prostatectomy: Size, smooth muscle atrophy, and curve

被引：27

作者：

McCullough A. ^{[1
]}

机构：

[1] Department of Urology, New York University School of Medicine, New York, NY 10016

来源：

Current Urology Reports | 2008年 / 9卷 / 6期

关键词：

Erectile Dysfunction; Radical Prostatectomy; Erectile Function; Tunica Albuginea; Penile Length;

D O I：

10.1007/s11934-008-0084-2

中图分类号：

学科分类号：

摘要：

Dr. Patrick Walsh's description of nerve-sparing prostatectomy was an important landmark in the surgical treatment of prostate cancer. Despite the dramatic improvement in postoperative potency rates, anecdotal reports of penile size loss were increasingly reported by patients. Experimental studies in animals revealed penile fibrosis and corporal cavernosal smooth muscle apoptosis after cavernosal nerve ablation. After an observational cross-sectional study demonstrated a time-dependent loss of penile length and circumference in men presenting with erectile dysfunction after nerve-sparing prostatectomy, several prospective studies supported the observational study. A prospective penile biopsy study before and after surgery demonstrated replacement of corporal smooth muscle with collagen and provided a possible explanation for loss of penile length. The mechanism has not yet been elucidated. This article reviews in detail the existing studies on loss of penile size after prostatectomy and possible etiologic mechanisms. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：492 / 499

页数：7

共 31 条

[1]

Walsh P.C., Donker P.J., Impotence following radical prostatectomy: Insight into etiology and prevention, J Urol, 128, pp. 492-497, (1982)

[2]

Lepor H., Gregerman M., Crosby R., Et al., Precise localization of the autonomic nerves from the pelvic plexus to the corpora cavernosa: A detailed anatomical study of the adult male pelvis, J Urol, 133, pp. 207-212, (1985)

[3]

Quinlan D.M., Epstein J.I., Carter B.S., Walsh P.C., Sexual function following radical prostatectomy: Influence of preservation of neurovascular bundles, J Urol, 145, pp. 998-1002, (1991)

[4]

Lee P.A., Reiter E.O., Genital size: A common adolescent male concern, Adolesc Med, 13, pp. 171-180, (2002)

[5]

Stulhofer A., How (un)important is penis size for women with heterosexual experience?, Arch Sex Behav, 35, pp. 5-6, (2006)

[6]

Wessells H., Lue T.F., McAninch J.W., Penile length in the flaccid and erect states: Guidelines for penile augmentation, J Urol, 156, pp. 995-997, (1996)

[7]

Fraiman M.C., Lepor H., McCullough A.R., Changes in penile morphometrics in men with erectile dysfunction after nerve-sparing radical retropubic prostatectomy, Mol Urol, 3, pp. 109-115, (1999)

[8]

O'Leary M.P., Fowler F.J., Lenderking W.R., Et al., A brief male sexual function inventory for urology, Urology, 46, pp. 697-706, (1995)

[9]

Munding M.D., Wessells H.B., Dalkin B.L., Pilot study of changes in stretched penile length 3 months after radical retropubic prostatectomy, Urology, 58, pp. 567-569, (2001)

[10]

Savoie M., Kim S.S., Soloway M.S., A prospective study measuring penile length in men treated with radical prostatectomy for prostate cancer, J Urol, 169, pp. 1462-1464, (2003)

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