In vitro evaluation of cytotoxic and inflammatory properties of silica nanoparticles of different sizes in murine RAW 264.7 macrophages

被引:0
|
作者
Margriet V. D. Z. Park
Iseult Lynch
Sonia Ramírez-García
Kenneth A. Dawson
Liset de la Fonteyne
Eric Gremmer
Wout Slob
Jacob J. Briedé
Andreas Elsaesser
C. Vyvyan Howard
Henk van Loveren
Wim H. de Jong
机构
[1] National Institute for Public Health and the Environment (RIVM),Laboratory for Health Protection Research
[2] Maastricht University,Department of Toxicogenomics
[3] University College Dublin,Centre for BioNano Interactions, School of Chemistry and Chemical Biology
[4] National Institute for Public Health and the Environment (RIVM),Centre for Substances and Integrated Risk Assessment
[5] University of Ulster,Nano Systems Biology, Centre for Molecular Biosciences
来源
Journal of Nanoparticle Research | 2011年 / 13卷
关键词
Nanoparticles; Silica; Cytotoxicity; Reactive oxygen species; Inflammation; Cytokines; Environmental and health effects;
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中图分类号
学科分类号
摘要
The biological response to four well-characterized amorphous silica nanoparticles was investigated in RAW 264.7 macrophages in view of their potential application as drug carriers to sites of inflammation. All silica nanoparticles-induced cell membrane damage, reduced metabolic activity, generated ROS and released various cytokines, but to different extents. Two silica nanoparticles of 34 nm (A and B) with different zetapotentials were more cytotoxic than (aggregated) 11 and 248 nm nanoparticles, while cytokines were mostly induced by the (aggregated) 11 nm and only one of the 34 nm nanoparticles (34A). The results indicate that specific silica nanoparticles may have counterproductive effects, for example when used as carriers of anti-inflammatory drugs. The physicochemical properties determining the response of nanoparticles vary for different responses, implying that a screening approach for the safe development of nanoparticles needs to consider the role of combinations of (dynamic) physicochemical properties and needs to include multiple toxicity endpoints.
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页码:6775 / 6787
页数:12
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