Prevalence and natural course of gastroesophageal reflux disease

被引：12
作者：
Labenz J. [1 ]
Labenz C. [2 ]
机构：
[1] Diakonie Klinikum – Jung-Stilling-Krankenhaus, Wichernstr. 40, Siegen
[2] Klinik für Gastroenterologie und Hepatologie, Universitätsklinikum Essen, Essen
来源：
Der Gastroenterologe | 2016年 / 11卷 / 2期
关键词：
Barrett‘s carcinoma; Barrett‘s esophagus; Endoskopy; Epidemiology; Gastroesophageal reflux disease;
D O I：
10.1007/s11377-016-0045-0
中图分类号：
学科分类号：
摘要：
Background: The epidemiology of a disease, in particular the natural course, is important for treatment planning and monitoring strategies. Objective: Incidence, prevalence, and natural course of gastroesophageal reflux disease (GERD). Materials and methods: Selective literature search in the database PubMed. Results: In industrialized countries, approximately 20 % of adults suffer from symptomatic GERD. In addition, asymptomatic esophageal reflux and Barrett esophagus was observed in more than 5 % of the general public in an endoscopic population based study. Spontaneous healing of GERD does occur, but in the majority of cases the disease is chronic. GERD is not a categorical disease. Approximately 25–30 % of patients have endoscopic progression of their disease over time. The cancer risk of Barrett esophagus is estimated to be 0.1–0.15 % per year, which is less than originally assumed. Overall, GERD is not associated with a shortened life expectancy. The epidemiology of extra-esophageal symptoms is largely unknown. Conclusion: GERD is a common disease with a good prognosis with regard to survival. Spontaneous recovery occurs as well as progression of endoscopic lesions. The cancer risk of Barrett esophagus is lower than expected; thus, surveillance should be limited to high-risk patients. © 2016, Springer-Verlag Berlin Heidelberg.
引用
收藏
页码：102 / 109
页数：7
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