Molecular definition of group 1 innate lymphoid cells in the mouse uterus

被引：0
作者：
Iva Filipovic
Laura Chiossone
Paola Vacca
Russell S. Hamilton
Tiziano Ingegnere
Jean-Marc Doisne
Delia A. Hawkes
Maria Cristina Mingari
Andrew M. Sharkey
Lorenzo Moretta
Francesco Colucci
机构：
[1] NIHR Cambridge Biomedical Research Centre,Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine
[2] University of Cambridge,Department of Physiology, Development and Neuroscience
[3] University of Cambridge,Centre for Trophoblast Research
[4] G. Gaslini Institute,Department of Experimental Medicine (DIMES)
[5] Genoa,Department of Immunology
[6] Policlinico San Martino IRCCS per l’Oncologia,Center of Excellence for Biomedical Research (CEBR)
[7] Genoa,Department of Pathology
[8] University of Genoa,Department of Immunology
[9] IRCCS Bambino Gesù Children’s Hospital,undefined
[10] University of Genova,undefined
[11] University of Cambridge,undefined
[12] Innate Pharma Research Labs,undefined
[13] Innate Pharma,undefined
[14] Pasteur Institute,undefined
来源：
Nature Communications | / 9卷
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摘要：
Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes+CD49a+ NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-β responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-γ. Eomes−CD49a+ ILC1s dominate before puberty, and specifically expand in second pregnancies when the expression of the memory cell marker CXCR6 is upregulated. These results identify trNK cells as the cellular hub of uterine group 1 ILCs, and mark CXCR6+ ILC1s as potential memory cells of pregnancy.
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