Does gap-free intensity modulated chemoradiation therapy provide a greater clinical benefit than 3D conformal chemoradiation in patients with anal cancer?

[1] Bartelink H(1996)UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research Lancet 348 1049-1054

[2] Roelofsen F(1997)Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J Clin Oncol 15 2040-2049

[3] Eschwege F(1996)Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol 14 2527-2539

[4] Rougier P(2003)Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups Eur J Cancer 39 45-51

[5] Bosset JF(2008)Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of RTOG 92-08 Int J Radiat Oncol Biol Phys 72 114-118

[6] Gonzalez DG(2011)Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal Cancer 117 3342-3351

[7] Peiffert D(2003)Results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal Int J Radiat Oncol Biol Phys 56 1259-1273

[8] van Glabbeke M(2010)Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11 J Clin Oncol 28 5061-5066

[9] Pierart M(1997)Time-dose considerations in the treatment of anal cancer Int J Radiat Oncol Biol Phys 39 651-657

[10] Flam M(2006)Chemoradiotherapy in patients with anal cancer: impact of length of unplanned treatment interruption on outcome Acta Oncol 45 728-735

[1] Bartelink H(1996)UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research Lancet 348 1049-1054

[2] Roelofsen F(1997)Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J Clin Oncol 15 2040-2049

[3] Eschwege F(1996)Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol 14 2527-2539

[4] Rougier P(2003)Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups Eur J Cancer 39 45-51

[5] Bosset JF(2008)Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of RTOG 92-08 Int J Radiat Oncol Biol Phys 72 114-118

[6] Gonzalez DG(2011)Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal Cancer 117 3342-3351

[7] Peiffert D(2003)Results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal Int J Radiat Oncol Biol Phys 56 1259-1273

[8] van Glabbeke M(2010)Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11 J Clin Oncol 28 5061-5066

[9] Pierart M(1997)Time-dose considerations in the treatment of anal cancer Int J Radiat Oncol Biol Phys 39 651-657

[10] Flam M(2006)Chemoradiotherapy in patients with anal cancer: impact of length of unplanned treatment interruption on outcome Acta Oncol 45 728-735