Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin

被引：0
作者：
Kyo-Hyun Park
JiYeon Kim
Suryun Jung
Kyung-hwa Sung
Yeon-Kyoung Son
Jung Min Bae
Bae-Hwan Kim
机构：
[1] Keimyung University,Department of Public Health
[2] Daegu Catholic University,Environmental Health Services Center
[3] Food & Supplement Health Claims,R&D Team
[4] Vitech,Department of Technical Assistance
[5] Agency for Korea National Food Cluster (AnFC),undefined
来源：
Toxicological Research | 2019年 / 35卷
关键词：
7-MEGA™ 500; Photoaging; Hairless mice; c-Jun; MMP-3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA™ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGA™ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGA™ 500. Therefore, the intake of 7-MEGA™ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.
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页码：353 / 359
页数：6
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