Oral Health and Cancer

被引：16
作者：
Chung M. [1 ]
York B.R. [1 ]
Michaud D.S. [1 ]
机构：
[1] Department of Public Health and Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, 02111, MA
来源：
Current Oral Health Reports | 2019年 / 6卷 / 2期
关键词：
Colorectal cancer; Fusobacterium nucleatum; Head and neck cancer; Lung cancer; Pancreatic cancer; Periodontal disease; Porphyromonas gingivalis;
D O I：
10.1007/s40496-019-0213-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: Recently published studies have provided new evidence for a role of oral health on risk of cancer. This review summarizes the latest research on this topic, including several new cohort studies that have examined associations on periodontal disease and cancer risk. Recent Findings: The most consistent findings for associations with periodontal disease have been observed for lung cancer; five out of seven studies have reported statistically significant increases in risk of lung cancer. For pancreatic, colorectal, and head and neck cancers, the associations are less consistent across studies, and the overall summary relative risk estimates are not statistically significant. However, these associations remain of interest, given the limitations of existing data (i.e., measurement error in periodontal disease assessment and small sample sizes), and growing support for biological mechanisms on how bacteria previously linked to periodontal disease may play a role in carcinogenesis. Summary: Future studies need improved assessment of periodontal disease in population-based studies to determine if heterogeneity of current studies resides with measurement error. Periodontal disease treatment and prevention may turn out to be important targetable cancer prevention strategies. © 2019, Springer Nature Switzerland AG.
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页码：130 / 137
页数：7
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