Release of lysozyme from electrospun PVA/lysozyme-gelatin scaffolds

被引：5

作者：

Yang D.-Z. ^{[1
]}

Long Y.-H. ^{[1
]}

Nie J. ^{[1
]}

机构：

[1] Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology

来源：

Frontiers of Materials Science in China | 2008年 / 2卷 / 3期

关键词：

Core-shell; Electrospinning; Gelatine; Lysozyme; Release;

D O I：

10.1007/s11706-008-0053-1

中图分类号：

学科分类号：

摘要：

This article describes an electrospinning process in fabricating ultra fine fibers with core-shell structure. A biodegradable polymer, poly(vinyl alcohol) (PVA), was used as the shell; lysozyme was a kind of antioxidant; and gelatin were used as the core.Morphology and microstructure of the ultra fine fibers were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) analysis. As a comparison, composite nanofiber PVA/lysozyme-gelatin blend was prepared by a normal electrospinning process. In vitro drug release behaviors of the nanofibrous membranes were determined in phosphatebuffered saline (PBS) solution. It was found that core-shell nanofibers PVA/lysozyme-gelatin obviously exhibit higher initial release rates compared to that of PVA/lysozymegelatin blend nanofibers. The current method may find wide application in controlled release of bioactive proteins and tissue engineering. © 2008 Higher Education Press and Springer-Verlag GmbH.

引用

页码：261 / 265

页数：4

共 15 条

[1]

Yoshimoto H., Shin Y.M., Terai H., Et al., A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering, Biomaterials, 24, pp. 2077-2082, (2003)

[2]

Shin M., Ishii O., Sueda T., Et al., Contractile cardiac grafts using a novel nanofibrous mesh, Biomaterials, 25, pp. 3717-3723, (2004)

[3]

Kenawy E.-R., Bowlin G.L., Mansfield K., Et al., Release of tetracycline hydrochloride from electrospun poly(ethyleneco-vinylacetate), poly(lactic acid), and a blend, Journal of Control Release, 81, pp. 57-64, (2002)

[4]

Luu Y.K., Kim K., Hsiao B.S., Et al., Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers, Journal of Control Release, 89, pp. 341-353, (2003)

[5]

Zong X.H., Ran S.F., Kim K., Et al., Structure and morphology changes during in vitro degradation of electrospun poly(glycolide-co-lactide) nanofiber membrane, Biomacromolecules, 4, pp. 416-423, (2003)

[6]

Zeng J., Xu X.Y., Chen X.S., Et al., Biodegradable electrospun fibers for drug delivery, Journal of Control Release, 92, pp. 227-231, (2003)

[7]

Katti D.S., Robinson K.W., Ko F.K., Et al., Bioresorbable nanofiber-based systems for wound healing and drug delivery: Optimization of fabrication parameters, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 70, pp. 286-296, (2004)

[8]

Kim K., Luu Y.K., Chang C., Et al., Incorporation and controlled release of a hydrophilic antibiotic using poly(lactideco-glycolide)-based electrospun nanofibrous scaffolds, Journal of Control Release, 9, pp. 47-56, (2004)

[9]

Sanders E.H., Kloefkorn R., Bowlin G.L., Et al., Two-phase electrospinning from a single electrified jet: Microencapsulation of aqueous reservoirs in poly(ethylene-co-vinyl acetate) fibers, Macromolecules, 36, pp. 3803-3805, (2003)

[10]

Sun Z.C., Zussman E., Yarin A.L., Et al., Compound core-shell polymer nanofibers by co-electrospinning, Advanced Materials, 15, pp. 1929-1932, (2003)

← 1 2 →