A cross-sectional study of the association between heavy metals and pan-cancers associated with sex hormones in NHANES 1999–2018

被引:0
作者
Hai-ming Cao
Ya-zhu Yang
Bao-yi Huang
Yunzhe Zhang
Yu Wu
Zi Wan
Lin Ma
机构
[1] The Reproductive Andrology,Faculty of Life Sciences and Medicine
[2] The Reproductive Medicine Center,The Urology Department
[3] The Seventh Affiliated Hospital of Sun Yat-Sen University,The Andrology Department
[4] The Reproductive Medicine Center,undefined
[5] The Seventh Affiliated Hospital of Sun Yat-Sen University,undefined
[6] King’s College London,undefined
[7] The Second Affiliated Hospital of Bengbu Medical University,undefined
[8] The First Affiliated Hospital of Sun Yat-Sen University,undefined
来源
Environmental Science and Pollution Research | 2023年 / 30卷
关键词
Heavy metal; Cancer; Sex hormone; Environmental pollution; Real world; NHANES;
D O I
暂无
中图分类号
学科分类号
摘要
Given the complexity of tumorigenesis, numerous studies have also shown that excessive exposure to heavy metals increases the risk of cancers and disrupts the secretion of sex hormones. However, the specific effects of heavy metals on cancers remain to be proven. To confirm the association between heavy metals and pan-cancer sex hormone levels among adults, 94,337 individuals from the National Health and Nutrition Examination Survey were assessed. We examined the associations between pan-cancers associated with sex hormones (ovarian, testicular, breast, and prostate cancers) and heavy metals in blood/urine. The methods (the WQS (weighted quantile sums) and SVYGLM (survey generalized linear model) regressions) were used to evaluate the association between sex hormone-related cancers and each metal category by incorporating covariates. To evaluate the overall effect of heavy metals and detect the dose–response relationship between the prevalence of pan-cancers associated with sex hormones and heavy metals, RCS (restricted cubic splines) were applied. Environmental exposure to heavy metals may be associated with pan-cancers associated with sex hormones in adults in the USA. Prostate cancer was inversely associated with blood cadmium while positively associated with blood lead, urinary tin, and thallium. Breast cancer was inversely associated with blood lead. Ovarian cancer was positively associated with blood cadmium. We also found a non-linear dose–response relationship between pan-cancers associated with sex hormones and heavy metals, which was non-parametric, using RCS models. The OR for breast cancer decreased along with the increase in lead concentration under approximately 20 µg/dl, while the OR for prostate cancer increased between urine thallium levels of approximately 0.17–1.1 ng/ml. Pan-cancers associated with sex hormones are associated with exposure to heavy metals. Considering the design of the NHANES study, further studies need to be conducted on other nationally representative surveys.
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页码:61005 / 61017
页数:12
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