Was ist gesichert in der Therapie der Sepsis?What is evidence-based in the treatment of sepsis?

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2013)Severe sepsis and septic shock N Engl J Med 369 2063-109

[3] Seymour CW(2020)S3 guideline sepsis-prevention, diagnosis, therapy, and aftercare : long version Med Klin Intensivmed Notfmed 115 37-1755

[4] Shankar-Hari M(2014)Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit Care Med 42 1749-827

[5] Annane D(2016)Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial Lancet Infect Dis 16 819-949

[6] Bauer M(2020)Effect of reduced exposure to vasopressors on 90-day mortality in older critically ill patients with vasodilatory hypotension: a randomized clinical trial JAMA 323 938-1863

[7] Angus DC(2015)Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials Intensive Care Med 41 1862-1572

[8] van der Poll T(2012)Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults JAMA 308 1566-1817

[9] Brunkhorst FM(2013)Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial JAMA 310 1809-2234

[10] Weigand MA(2008)A comparison of epinephrine and norepinephrine in critically ill patients Intensive Care Med 34 2226-518

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2013)Severe sepsis and septic shock N Engl J Med 369 2063-109

[3] Seymour CW(2020)S3 guideline sepsis-prevention, diagnosis, therapy, and aftercare : long version Med Klin Intensivmed Notfmed 115 37-1755

[4] Shankar-Hari M(2014)Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit Care Med 42 1749-827

[5] Annane D(2016)Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial Lancet Infect Dis 16 819-949

[6] Bauer M(2020)Effect of reduced exposure to vasopressors on 90-day mortality in older critically ill patients with vasodilatory hypotension: a randomized clinical trial JAMA 323 938-1863

[7] Angus DC(2015)Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials Intensive Care Med 41 1862-1572

[8] van der Poll T(2012)Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults JAMA 308 1566-1817

[9] Brunkhorst FM(2013)Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial JAMA 310 1809-2234

[10] Weigand MA(2008)A comparison of epinephrine and norepinephrine in critically ill patients Intensive Care Med 34 2226-518