The genetics of ADHD: A literature review of 2005

被引：45

作者：

Khan S.A. ^{[1
]}

Faraone S.V. ^{[1
]}

机构：

[1] SUNY Upstate Medical University, Syracuse, NY 13210

来源：

Current Psychiatry Reports | 2006年 / 8卷 / 5期

关键词：

Acad Child Adolesc Psychiatry; DRD4 Gene;

D O I：

10.1007/s11920-006-0042-y

中图分类号：

学科分类号：

摘要：

Investigations into the genetic basis of attention-deficit/hyperactivity disorder (ADHD) continue to yield compelling results as candidate gene studies reveal more information about this elusive disorder. Family, twin, and adoption studies further the notion that ADHD is a highly heritable disorder with direct genetic and environmental influence. The year 2005 saw many ADHD candidate gene studies, with most focused on the catecholaminergic candidates. Although many genes were studied in 2005, a large portion of findings has been supportive of the roles of dopaminergic genes' relationship to clinical phenotypes and drug response. These studies often require replication. Clinical implications continue to be speculative, as larger sample sizes are needed to validate findings to the general population. Further understanding of endophenotypes and the impact of comorbidities also is necessary for proper clinical intervention. Forthwith, we provide a summary of ADHD genetic studies published in 2005. Copyright © 2006 by Current Science Inc.

引用

页码：393 / 397

页数：4

共 25 条

[1]

Faraone S.V., Sergeant J., Gillberg C., Biederman J., The worldwide prevalence of ADHD: Is it an American condition?, World Psychiatry, 2, pp. 104-113, (2003)

[2]

Faraone S.V., Perlis R.H., Doyle A.E., Et al., Molecular genetics of attention deficit hyperactivity disorder, Biol Psychiatry, 57, pp. 1313-1323, (2005)

[3]

Faraone S., Khan S., Candidate gene studies of attention deficit activity disorder, J Clin Psychiatry, (2006)

[4]

Bakker S.C., van der Meulen E.M., Buitelaar J.K., Et al., A whole-genome scan in 164 Dutch sib pairs with attention-deficit/ hyperactivity disorder: Suggestive evidence for linkage on chromosomes 7p and 15q, Am J Hum Genet, 72, pp. 1251-1260, (2003)

[5]

Smalley S.L., Kustanovich V., Minassian S.L., Et al., Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism, Am J Hum Genet, 71, pp. 959-963, (2002)

[6]

Fisher S.E., Francks C., McCracken J.T., Et al., A genomewide scan for loci involved in attention-deficit/hyperactivity disorder, Am J Hum Genet, 70, pp. 1183-1196, (2002)

[7]

Arcos-Burgos M., Castellanos F.X., Pineda D., Et al., Attention-deficit/hyperactivity disorder in a population isolate: Linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11, Am J Hum Genet, 75, pp. 998-1014, (2004)

[8]

Arnsten A.F., Li B.M., Neurobiology: Of executive functions: Catecholamine influences on prefrontal cortical functions, Biol Psychiatry, 57, pp. 1377-1384, (2005)

[9]

Bobb A.J., Addington A.M., Sidransky E., Et al., Support for association between ADHD and two candidate genes: NET1 and DRD1, Am J Med Genet B Neuropsychiatr Genet, 134, pp. 67-72, (2005)

[10]

Hamarman S., Fossella J., Ulger C., Et al., Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: A pharmacogenetic study, J Child Adolesc Psychopharmacol, 14, pp. 564-574, (2004)

← 1 2 3 →