Advances in the Genetics of Spondyloarthritis and Clinical Implications

被引：0
作者：
Darren D. O’Rielly
Proton Rahman
机构：
[1] Memorial University of Newfoundland,Faculty of Medicine
[2] Memorial University of Newfoundland,undefined
来源：
Current Rheumatology Reports | 2013年 / 15卷
关键词：
Genetics; Candidate genes; GWAS; Spondyloarthritis; Psoriatic arthritis; Psoriasis; Ankylosing spondylitis; Pathogenesis; Innate immunity; Adaptive immunity; Bone remodeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylitis (AS) and psoriatic arthritis (PsA). SpA is a major health challenge given the propensity to affect young adults and the potential requirement for lifelong treatment. Although the precise etiology of SpA is unknown, there is mounting evidence that these diseases are a result of complex interplay of genetic, environmental, and immunological factors. In this review on SpA, we will discuss genetic variants with genome-wide significance, highlight potential clinical application of genetic variants, and discuss challenges in further elucidating the genetic basis of SpA.
引用
收藏
相关论文
共 241 条
[61]  
Spencer CC(2008)IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype Proc Natl Acad Sci U S A 105 20846-1146
[62]  
Pointon JJ(2010)Role of Th17 cells in human autoimmune arthritis Arthritis Rheum 62 2876-640
[63]  
Lin Z(2006)Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment Ann Rheum Dis 65 1551-3201
[64]  
Bei JX(2009)Osteoclasts and Arthritis J Bone Miner Res 24 1142-1453
[65]  
Shen M(2007)IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats Arthritis Res Ther 9 R96-811
[66]  
Cauli A(2009)Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial Lancet 373 633-9
[67]  
Mathieu A(2010)Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss J Immunol 184 3191-592
[68]  
de Cid R(2008)Genetics of psoriasis and psoriatic arthritis: update and future direction J Rheumatol 35 1449-429
[69]  
Riveira-Munoz E(2007)HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis Ann Rheum Dis 66 807-593
[70]  
Zeeuwen PL(2006)Disease-specific alleles of the MHC Class I related gene, MICA, are associated with type I psoriasis and psoriatic arthritis [abstract FC 10] Br J Dermatol 154 4-1002
234567891011