Advances in the Genetics of Spondyloarthritis and Clinical Implications

被引：0
作者：
Darren D. O’Rielly
Proton Rahman
机构：
[1] Memorial University of Newfoundland,Faculty of Medicine
[2] Memorial University of Newfoundland,undefined
来源：
Current Rheumatology Reports | 2013年 / 15卷
关键词：
Genetics; Candidate genes; GWAS; Spondyloarthritis; Psoriatic arthritis; Psoriasis; Ankylosing spondylitis; Pathogenesis; Innate immunity; Adaptive immunity; Bone remodeling;
D O I：
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中图分类号：
学科分类号：
摘要：
Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylitis (AS) and psoriatic arthritis (PsA). SpA is a major health challenge given the propensity to affect young adults and the potential requirement for lifelong treatment. Although the precise etiology of SpA is unknown, there is mounting evidence that these diseases are a result of complex interplay of genetic, environmental, and immunological factors. In this review on SpA, we will discuss genetic variants with genome-wide significance, highlight potential clinical application of genetic variants, and discuss challenges in further elucidating the genetic basis of SpA.
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