An efficient and facile synthesis of new tetracyclic fused pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones

被引：0
作者：
Mohsen A.-M. Gomaa
Huda A. Ali
机构：
[1] Minia University,Department of Chemistry, Faculty of Science
来源：
Molecular Diversity | 2018年 / 22卷
关键词：
Pyrazolo[4,3-; ][1,2,4]triazino[4,5-; ]quinolone; Amidrazone; (1,5-dihydro-3-methyl-5-oxo-1-phenyl-4; -pyrazol-4-ylidene)propanedinitrile; Dearomatization;
D O I：
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中图分类号：
学科分类号：
摘要：
Reaction of amidrazones 1a–1i with (1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)propanedinitrile (2) in ethyl acetate solution in one-step reaction led to the formation of unprecedented pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones 3a–3g along with pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-12b-oles 3h–3m in moderate to excellent yields. These novel heterocycles were formed via a Michael addition reaction followed by intramolecular cyclization via a dearomatization process.
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页码：969 / 977
页数：8
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