Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

被引：0

作者：

Gabriella Marucci

Angeli Piero

Livio Brasili

Michela Buccioni

Dario Giardinà

Ugo Gulini

Alessandro Piergentili

Gianni Sagratini

机构：

[1] University of Camerino,Department of Chemical Sciences

[2] University of Modena and Reggio Emilia,Department of Pharmaceutical Sciences

来源：

Medicinal Chemistry Research | 2005年 / 14卷

关键词：

Trans Isomer; Functional Test; Trimethylammonium; Dioxolanes; Methiodides;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Geometric cis, trans isomers, derivatives of 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests with rabbit vas deferens (putative M1), guinea-pig heart (M2) and guinea-pig ileum (M3). The effect of the replacement of a trimethylammonium group with a dimethysulfonium in the two rings was also evaluated. Pharmacological results indicate that the 1,3-dioxane nucleus shows the highest stereoselective values on the studied receptors.

引用

页码：274 / 296

页数：22

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