Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

被引：0
|
作者：
Gabriella Marucci
Angeli Piero
Livio Brasili
Michela Buccioni
Dario Giardinà
Ugo Gulini
Alessandro Piergentili
Gianni Sagratini
机构：
[1] University of Camerino,Department of Chemical Sciences
[2] University of Modena and Reggio Emilia,Department of Pharmaceutical Sciences
来源：
Medicinal Chemistry Research | 2005年 / 14卷
关键词：
Trans Isomer; Functional Test; Trimethylammonium; Dioxolanes; Methiodides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Geometric cis, trans isomers, derivatives of 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests with rabbit vas deferens (putative M1), guinea-pig heart (M2) and guinea-pig ileum (M3). The effect of the replacement of a trimethylammonium group with a dimethysulfonium in the two rings was also evaluated. Pharmacological results indicate that the 1,3-dioxane nucleus shows the highest stereoselective values on the studied receptors.
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页码：274 / 296
页数：22
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