Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats

被引：72

作者：

Sengottaiyan A. ^{[1
]}

Aravinthan A. ^{[2
]}

Sudhakar C. ^{[1
]}

Selvam K. ^{[1
]}

Srinivasan P. ^{[1
]}

Govarthanan M. ^{[1
,3
]}

Manoharan K. ^{[4
]}

Selvankumar T. ^{[1
]}

机构：

[1] Department of Biotechnology, Mahendra Arts and Science College (Autonomous), Tamil Nadu, Kalippatti, Namakkal

[2] College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan

[3] Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan

[4] Raja Duraisingam Government Arts and Science College, Tamil Nadu, Sivagangai

来源：

Journal of Nanostructure in Chemistry | 2016年 / 6卷 / 1期

关键词：

Alloxan; Animal model; Diabetes mellitus; Silver nanoparticles; Solanum nigrum;

D O I：

10.1007/s40097-015-0178-6

中图分类号：

学科分类号：

摘要：

Solanum nigrum, a medicinal plant, traditionally used in treating diabetes mellitus. In this study, we used the leaf extract of the plant to synthesize silver nanoparticles (AgNPs), as a proposition to treat alloxan-induced diabetic rats. The phytosynthesised AgNPs were analyzed using UV–visible and Fourier transform infra-red spectroscopy for their functional groups. Transmission electron microscopy revealed that, the synthesized particles are found to be 4–25 nm in size. Monodispersed and spherical nature of synthesized AgNPs were shown by scanning electron microscope and the presence of Ag in the AgNPs was confirmed by energy dispersive spectrum. The phytosynthesised AgNPs were evaluated for its antidiabetic activity in alloxan-induced diabetic rats. AgNPs-treated diabetic rats found to be significantly improved the dyslipidemic condition as seen in the diabetic control. Furthermore, it also reduced the blood glucose level over the period of treatment. The improvement in body weight was also found to be evidence for S. nigrum extract-mediated AgNPs as a potential antidiabetic agent against alloxan-induced diabetic rats. © 2015, The Author(s).

引用

页码：41 / 48

页数：7

共 38 条

[1] Alvin C.P., David Allesio D.D., Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycaemia, Goodman and Gilman’s the Pharmacological Basis of Therapeutics, (2011)
[2] Foster D.W., Diabetes Mellitus Harrison’s Principles of Internal Medicine, pp. 1979-1981, (1994)
[3] El-Amrani F., Rhallab A., Alaoui T., El-Badaoui K., Chaki S., Hypoglycaemic effect of Thymelaea hirsuta in normal and streptozotocin-induced diabetic rats, J. Med. Plants Res., 3, 9, pp. 625-629, (2009)
[4] Singh U., Kochhar A., Singh S., Blood glucose lowering potential of some herbal plants, J. Med. Plants Res., 5, 19, pp. 4691-4695, (2011)
[5] Modi P., Diabetes beyond insulin: review of new drugs for treatment of diabetes mellitus, Curr. Drug Discov. Technol., 4, pp. 39-47, (2007)
[6] Baynes J.W., Thorpe S.R., The role of oxidative stress in diabetic complications, Endocrinol. J., 3, pp. 277-284, (1996)
[7] Alarcon-Aguilara F.J., Roman-Ramos R., Perez-Gutierrez S., Aguilar-Contreras A., Contreras-Webar C.C., Felores-Saenz J.L., Study of the anti-hyperglycemic effect of plants used as antidiabetics, J. Ethnopharmacol., 61, pp. 101-110, (1998)
[8] Grover J.K., Yadav S., Vats V., Medicinal plants of India with antidiabetic potential, J. Ethanopharmacol., 81, pp. 81-100, (2002)
[9] Jain R., Sharma A., Gupta S., Sarethy I.P., Gabrani R., Solanum nigrum: current perspectives on therapeutic properties, Altern. Med. Rev., 6, pp. 78-85, (2011)
[10] Sohrabipour S., Kharazmi F., Soltani N., Kamalinejad M., Effect of the administration of Solanum nigrum fruit on blood glucose, lipid profiles, and sensitivity of the vascular mesenteric bed to phenylephrine in streptozotocin-induced diabetic rats, Med. Sci. Monit. Basic Res., 19, pp. 133-140, (2013)

← 1 2 3 4 →