Opportunities and challenges of translational 3D bioprinting

被引：418
作者：
Murphy S.V. [1 ]
De Coppi P. [2 ]
Atala A. [1 ]
机构：
[1] Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC
[2] Stem Cells & Regenerative Medicine Section, University College London, Great Ormond Street Institute of Child Health, London
来源：
Nature Biomedical Engineering | 2020年 / 4卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/s41551-019-0471-7
中图分类号：
学科分类号：
摘要：
3D-printed orthopaedic devices and surgical tools, printed maxillofacial implants and other printed acellular devices have been used in patients. By contrast, bioprinted living cellular constructs face considerable translational challenges. In this Perspective, we first summarize the most recent developments in 3D bioprinting for clinical applications, with a focus on how 3D-printed cartilage, bone and skin can be designed for individual patients and fabricated using the patient’s own cells. We then discuss key translational considerations, such as the need to ensure close integration of the living device with the patient’s vascular network, the development of biocompatible bioinks and the challenges in deriving a physiologically relevant number of cells. Lastly, we outline untested regulatory pathways, as well as logistical challenges in material sourcing, manufacturing, standardization and transportation. © 2019, Springer Nature Limited.
引用
收藏
页码：370 / 380
页数：10
相关论文
共 123 条
[1]  
Tack P., Victor J., Gemmel P., Annemans L., 3D-printing techniques in a medical setting: a systematic literature review, Biomed. Eng. Online, 15, (2016)
[2]  
Di Prima M., Coburn J., Hwang D., Kelly J., Khairuzzaman A., Ricles L., Additively manufactured medical products–the FDA perspective, 3D Print. Med., 2, (2016)
[3]  
Ventola C.L., Medical applications for 3D printing: current and projected uses, Pharma. Ther., 39, pp. 704-711, (2014)
[4]  
Ma L., Et al., 3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee, Sci. Rep., 7, (2017)
[5]  
Li B., Et al., Application of a novel three-dimensional printing genioplasty template system and its clinical validation: a control study, Sci. Rep., 7, (2017)
[6]  
Zopf D.A., Hollister S.J., Nelson M.E., Ohye R.G., Green G.E., Bioresorbable airway splint created with a three-dimensional printer, New Eng. J. Med., 368, pp. 2043-2045, (2013)
[7]  
Morrison R.J., Et al., Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients, Sci. Transl. Med., 7, pp. 264-285, (2015)
[8]  
Highlights of Prescribing Information—Spritam 2015, (2017)
[9]  
Mankin H.J., Mow V.C., Buckwalter J.A., Iannotti J.P., Ratcliffe A., Articular cartilage structure, composition, and function, Orthopaed. Basic Sci., 2, pp. 443-470, (2000)
[10]  
Buckwalter J., Mankin H., Articular cartilage: tissue design and chondrocyte-matrix interactions, Instr. Course Lect., 47, pp. 477-486, (1998)
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