Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles

被引：0
作者：
Keiko Hojo
Asaki Hara
Hiroyuki Kitai
Mare Onishi
Hideki Ichikawa
Yoshinobu Fukumori
Koichi Kawasaki
机构：
[1] Kobe Gakuin University,Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences
来源：
Chemistry Central Journal | / 5卷
关键词：
Peptide Synthesis; Fmoc; DIEA; Protected Amino Acid; Acid Nanoparticles;
D O I：
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学科分类号：
摘要：
Due to the vast importance of peptides in biological processes, there is an escalating need for synthetic peptides to be used in a wide variety of applications. However, the consumption of organic solvent is extremely large in chemical peptide syntheses because of the multiple condensation steps in organic solvents. That is, the current synthesis method is not environmentally friendly. From the viewpoint of green sustainable chemistry, we focused on developing an organic solvent-free synthetic method using water, an environmentally friendly solvent. Here we described in-water synthesis technology using water-dispersible protected amino acids.
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