Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway

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作者
Pingping Sun
Yuemin Zhang
Lilan Sun
Na Sun
Jinguang Wang
Huagang Ma
机构
[1] Weifang People’s Hospital,Reproductive Medicine Center
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关键词
Kisspeptin; Polycystic ovary syndrome; Granulosa cell; Oxidative stress; Apoptosis; PI3K/AKT/ERK signalling;
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摘要
Kisspeptin expression is decreased in ovaries of PCOS ratKisspeptin promotes proliferation and inhibits apoptosis of granulosa cellsKisspeptin alleviates oxidative stress of granulosa cellsKisspeptin activates PI3K/AKT/ERK signalling pathway
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