Infant apnea and gastroesophageal reflux: A critical review and framework for further investigation

被引：31

作者：

Slocum C. ^{[1
]}

Hibbs A.M. ^{[1
]}

Martin R.J. ^{[1
]}

Orenstein S.R. ^{[1
]}

机构：

[1] Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland

来源：

Current Gastroenterology Reports | 2007年 / 9卷 / 3期

关键词：

Lower Esophageal Sphincter; Obstructive Apnea; Transient Lower Esophageal Sphincter Relax; Multichannel Intraluminal Impedance; Mixed Apnea;

D O I：

10.1007/s11894-007-0022-3

中图分类号：

学科分类号：

摘要：

Gastroesophageal reflux and apnea of prematurity are both common occurences in premature infants. However, a casual relationship between the two remains controversial. Strong physiologic evidence indicates that a variety of protective reflex responses may elicit laryngeal adduction and apnea. Although a potential link between gastroesophageal reflux and apnea may exist through this pathway, clinical studies can be cited to either support or refute such a link in premature infants. The majority of gastroesophageal reflux episodes do not appear to be related to apnea. In a specific subset of events, a casual relationship may exist. Whether this is related to the character of the reflux episode or to a pre-disposition in a subpopulation of infants is nuclear. This review presents the evidence for and againts an association between gastroesophageal reflux and apnea, discusses techniques used in their evaluation, and identifies approaches for future investigation. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：219 / 224

页数：5

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