NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population

被引：0
作者：
A H Poon
C Laprise
M Lemire
T J Hudson
E Schurr
机构：
[1] McGill Centre for the Study of Host Resistance,Department of Biochemistry
[2] Research Institute of the McGill University Health Centre,Department of Medicine and Human Genetics
[3] McGill University,undefined
[4] Université du Québec à Chicoutimi,undefined
[5] Community Genomic Medicine Centre,undefined
[6] University of Montreal,undefined
[7] Chicoutimi Hospital,undefined
[8] McGill University and Genome Québec Innovation Centre,undefined
[9] McGill University,undefined
来源：
Genes & Immunity | 2005年 / 6卷
关键词：
genetic predisposition; polymorphism; natural resistance-associated macrophages protein 1; asthma; tuberculosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Reduced infection by mycobacteria, including Mycobacterium tuberculosis, may be partly responsible for increased prevalence of allergic and autoimmune diseases in developed countries. In a murine model of innate resistance to mycobacteria, the Nramp1 gene has been shown to affect asthma susceptibility. From this observation, it was proposed that human NRAMP1 may be a modulator of asthma risk in human populations. To experimentally test the candidacy of NRAMP1 in asthma susceptibility, we characterized five genetic variants of NRAMP1 (5′CAn, 274C>T, 469+14G>C, D543N, and 1729+del4) in an asthma family-based cohort from northeastern Quebec. We did not observe any significant association between NRAMP1 variants (either allele or haplotype specific) with asthma, atopy, or serum immunoglobulin E levels. These results demonstrate that, in spite of direct involvement of Nramp1 in a murine asthma model, in human populations NRAMP1 is not likely to be a major contributor to the genetic etiology of asthma and asthma-related phenotypes.
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页码：519 / 527
页数：8
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