A Study of Haloperidol Inclusion Complexes with β-Cyclodextrin Using Phase Solubility, NMR Spectroscopy and Molecular Modeling Techniques

被引：0
|
作者：
Mahmoud M. Al Omari
Mohammad B. Zughul
J. Eric D. Davies
Adnan A. Badwan
机构：
[1] The Jordanian Pharmaceutical Manufacturing Company,Department of Chemistry
[2] University of Jordan,Department of Environmental Science
[3] Lancaster University,undefined
来源：
Journal of Solution Chemistry | 2009年 / 38卷
关键词：
Haloperidol; Aqueous p; Cyclodextrin; Hydrophobic effect; H-NMR; Molecular modeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Guest-host interactions of haloperidol (Halo) with β-cyclodextrin (β-CD) have been investigated using several techniques including phase solubility diagrams (PSD), proton nuclear magnetic resonance (1H-NMR), X-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and molecular mechanical modeling (MM+).
引用
收藏
页码：669 / 683
页数：14
相关论文
共 50 条
  • [21] Inclusion complexes of pantoprazole with β-cyclodextrin and cucurbit[7]uril: experimental and molecular modeling study
    FakhrEldin O. Suliman
    Beena Varghese
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2018, 91 : 179 - 188
  • [22] Thermodynamic study of β-cyclodextrin-dye inclusion complexes using gradient flow injection technique and molecular modeling
    Izadmanesh, Y.
    Ghasemi, Jahan B.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2016, 165 : 54 - 60
  • [23] Study of the solubility, photostability and structure of inclusion complexes of carvedilol with β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin
    Ivana Savic-Gajic
    Ivan M. Savic
    Vesna D. Nikolic
    Ljubisa B. Nikolic
    Mirjana M. Popsavin
    Agnes J. Kapor
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2016, 86 : 7 - 17
  • [24] A study of β-cyclodextrin inclusion complexes with progesterone and hydrocortisone using rotating frame Overhauser spectroscopy
    Forgo, P
    Göndös, G
    MONATSHEFTE FUR CHEMIE, 2002, 133 (01): : 101 - 106
  • [25] Study of the solubility, photostability and structure of inclusion complexes of carvedilol with β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin
    Savic-Gajic, Ivana
    Savic, Ivan M.
    Nikolic, Vesna D.
    Nikolic, Ljubisa B.
    Popsavin, Mirjana M.
    Kapor, Agnes J.
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2016, 86 (1-2) : 7 - 17
  • [26] Preparation, characterization, and molecular modeling of sesamol/β-cyclodextrin derivatives inclusion complexes
    Han, Ping
    Zhong, Yuanyuan
    An, Ning
    Lu, Shiling
    Wang, Qingling
    Dong, Juan
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 339
  • [27] NMR spectroscopic study of cyclodextrin inclusion complexes with A-007 prodrugs
    Sagiraju, Sarada
    Jursic, Branko S.
    CARBOHYDRATE RESEARCH, 2008, 343 (07) : 1180 - 1190
  • [28] The modes of complexation of benzimidazole with aqueous β-cyclodextrin explored by phase solubility, potentiometric titration, 1H-NMR and molecular modeling studies
    F. O. Yousef
    M. B. Zughul
    A. A. Badwan
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 57 : 519 - 523
  • [29] STUDIES OF CYCLODEXTRIN INCLUSION COMPLEXES .1. THE SALBUTAMOL-CYCLODEXTRIN COMPLEX AS STUDIED BY PHASE SOLUBILITY AND DSC
    MARQUES, HMC
    HADGRAFT, J
    KELLAWAY, IW
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 63 (03) : 259 - 266
  • [30] Enhanced Solubility of Albendazole in Cyclodextrin Inclusion Complex: A Molecular Modeling Approach and Physicochemical Evaluation
    de Melo, Camila Gomes
    Gonzaga da Costa, Lucas Amadeu
    Rabello, Marcelo Montenegro
    Wanderley Sales, Victor de Albuquerque
    Ferreira, Aline Silva
    Dantas da Silva, Paulo Cesar
    Vicente Nishimura, Rodolfo Hideki
    Ferreira da Silva, Rosali Maria
    Rolim, Larissa de Araujo
    Rolim Neto, Pedro Jose
    CURRENT DRUG DELIVERY, 2022, 19 (01) : 86 - 92
12345