Analysis of the Expression of MICA in Small Intestinal Mucosa of Patients with Celiac Disease

被引：0
作者：
Ainhoa Martín-Pagola
Lourdes Ortiz
Gustavo Pérez De Nanclares
Juan Carlos Vitoria
Luis Castaño
J. Ramón Bilbao
机构：
[1] Hospital de Cruces,Endocrinology and Diabetes Research Units
[2] Hospital de Cruces,Pediatric Gastroenterology, Unit
[3] University of the Basque Country,Department of Pediatrics
[4] University of the Basque Country,Department of Nursing
来源：
Journal of Clinical Immunology | 2003年 / 23卷
关键词：
Celiac disease; biopsy; expression; IFN-γ; gastrointestinal epithelium;
D O I：
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学科分类号：
摘要：
The MHC class I chain-related A gene (MICA) is expressed in gastrointestinal epithelium and functions as an immune activation signal under stress conditions. MICA protein binds to NKG2D, a receptor of γ δ T cells containing the TCR variable region Vδ1, which are the most abundant subset of T cells in the intestinal epithelium. Ingested gluten in patients with celiac disease (CD) may function as a stress signal for the epithelial cells, and could enhance MICA expression on their surface. In this study, we have analyzed MICA expression in intestinal biopsy specimens from newly diagnosed and treated CD patients and controls. Quantitative RT-PCR analysis did not show differences in MICA expression among the three groups. With these results, we conclude that overexpression of MICA does not seem to play an important role in the pathogenesis of CD, at least at the time of diagnosis.
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页码：498 / 503
页数：5
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