Severity and duration of mental deficiency symptoms after intravenous administration of propofol

被引：0
作者：
S. Seidl
R. Hausmann
J. Neisser
H. -D. Janisch
P. Betz
机构：
[1] University Erlangen-Nürnberg,Institute for Forensic Medicine
[2] Surgery for Gastroenterology,undefined
来源：
International Journal of Legal Medicine | 2007年 / 121卷
关键词：
Propofol; Narcotics; Deficiency symptoms; Memory; Attention; Driving ability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The severity and duration of cognitive performance capacity deficits after intravenous administration of propofol were determined using the validated psychological test procedure syndrome short test (SKT), a simple reaction test and original driving licence exam questions. The test battery was performed before, immediately after, as well as 1 and 2 h after propofol administration in 23 persons. Immediately after propofol anaesthesia, six individuals had a slight performance loss, and four subjects showed mild deficits, consistent with medium organic neuropsychologic disorder or dementia. The status of the subjects rapidly changed for the better, and 2 h after propofol anaesthesia, only one person (4%) showed slight deficits of memory and attention. Therefore, it is suggested that patients refrain from any participation in road traffic for at least 2 h after propofol anaesthesia. Driving a car should not be admitted until an interval of 6 h has elapsed.
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页码：281 / 285
页数：4
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共 47 条
  • [1] Cirimele V(2002)Determination of chronic abuse of the anesthetic agents midazolam and propofol as demonstrated by hair analysis Int J Legal Med 116 54-57
  • [2] Kintz P(2000)Blood propofol concentration and psychomotor effects on driving skills Br J Anaesth 85 396-400
  • [3] Doray S(1998)Schweregrad und Zeitdauer forensisch relevanter Wirkungen nach oraler Aufnahme von Midazolam Rechtsmedizin 8 64-68
  • [4] Ludes B(2001)Death after excessive propofol abusei Int J Legal Med 114 248-251
  • [5] Grant SA(2005)Preparation, premedication, and surveillance Endoscopy 37 101-109
  • [6] Murdoch J(2003)Preparation, premedication, and surveillance Endoscopy 35 103-111
  • [7] Millar K(1997)Evidence of the cross-cultural stability of the factor structure of the SKT short test for assessing deficits of memory and attention Int Psychogeriatr 9 139-153
  • [8] Kenny GNC(2004)Propofol: therapeutic indications and side-effects Curr Pharm Des 10 3639-3649
  • [9] Hausmann R(1996)Évaluation des functions cognitives après anesthésie au propofol Ann Fr Anesth Reanim 15 1155-1161
  • [10] Betz P(2003)General anesthesia does not impair simulator driving skills in volunteers in the immediate recovery period—a pilot study Can J Anaesth 50 238-245
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