Anabolic effect of prostaglandins

被引：3
作者：
Raisz L.G. [1 ]
机构：
[1] Musculoskeletal Institute, University of Connecticut Health Center, Farmington
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2006年 / 4卷 / 2期
关键词：
Bone formation; COX-2; PGE[!sub]2[!/sub; Prostaglandins;
D O I：
10.1385/BMM:4:2:123
中图分类号：
学科分类号：
摘要：
Prostaglandins, particularly PGE2, have been shown to stimulate bone formation in a number of circumstances. Endogenous prostaglandins may be important in heterotopic ossification and fracture healing. The major source of prostaglandins in bone is the inducible form of cyclooxygenase (COX)-2 and inhibition of COX-2 may impair bone formation. Recent studies using selective agonists for the prostaglandin EP2 and EP4 receptors, which stimulate cAMP in bone cells, have suggested that these might be used clinically to accelerate bone formation, particularly when used locally. © Copyright 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.
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页码：123 / 127
页数：4
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