Production of a monoclonal antibody by ascites, hollow fiber system, and transgenic plants for vaccine production using CB.Hep-1 mAb as a study case

被引：0
作者：
Rodolfo Valdés
Andrés Tamayo
Marcos González
Sigifredo Padilla
Déborah Geada
William Ferro
Lorely Milá
Leonardo Gómez
Rosario Alemán
Alberto Leyva
Cristina García
Otto Mendoza
Tatiana Alvarez
Lamay Dorta
Yanet Villega
Dobián Cecilia
Hasel Aragón
Tatiana González
Maylín La O
Jorge López
机构：
[1] Center for Genetic Engineering and Biotechnology,Monoclonal Antibody Production Department
[2] Institute of Tobacco Research,Quality Assurance Direction
[3] Center for Genetic Engineering and Biotechnology,Process Control Derpatment
[4] Center for Genetic Engineering and Biotechnology,Quality Control Direction
[5] Center for Genetic Engineering and Biotechnology,undefined
来源：
Biotechnology and Bioprocess Engineering | 2012年 / 17卷
关键词：
ascites; hollow fiber bioreactor; plantibody; monoclonal antibody; transgenic plants;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Monoclonal antibody (mAb) production methods (ascites, in vitro technologies, transgenic animals, and dicot or monocot transgenic plants; moss, algae) have been improved since they were first developed in 1975. In this study, we illustrate a summary of a study case in which mice, a hollow fiber system, and tobacco transgenic plants were assessed for the production of mAb for vaccine manufacturing and vaccine production.
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页码：145 / 159
页数：14
相关论文
共 201 条
[1]  
Payne W. J.(1998)Clinical laboratory applications of monoclonal antibodies Clin. Microbiol. Rev. 1 313-329
[2]  
Marshall D. L.(1975)Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 495-497
[3]  
Shockley R. K.(1990)Increased monoclonal antibody ascites production in mice primed with Freund’s incomplete adjuvant J. Immunol. Method 129 227-231
[4]  
Martin W. J.(1997)Monoclonal antibody Production; the report and recommendations of ECVAM Workshop 23 ATLA 25 121-137
[5]  
Köhler G.(1998)Critical steps in the production of polyclonal and monoclonal antibodies: evaluation and recommendations IALR (2005) 46 269-279
[6]  
Milstein C.(1995) production of monoclonal antibodies in high concentration in a new and easy to handle modular minifermentor J. Immunol. 179 13-29
[7]  
Jones S. L.(1998)Large-scale production of murine monoclonal antibodies using hollow fiber bioreactors BioTechniques 6 762-767
[8]  
Cox J. C.(1983)Expression of bacterial genes in plant cells Proc. Natl. Acad. Sci. USA. 80 4803-4807
[9]  
Pearson J. E.(2003)The production of recombinant pharmaceutical proteins in plants Nature Rev. 4 794-805
[10]  
Marx U.(1997)Plants as bioreactors for biopharmaceuticals: Regulatory considerations Tibetech. 15 45-50
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