Esophageal Adenocarcinoma: Treatment Modalities in the Era of Targeted Therapy

被引:0
|
作者
Kaushik Mukherjee
A. Bapsi Chakravarthy
Laura W. Goff
Wael El-Rifai
机构
[1] Vanderbilt University Medical Center,Section of Surgical Sciences
[2] Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center,Department of Radiation Oncology
[3] Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center,Division of Medical Oncology
[4] Vanderbilt-Ingram Cancer Center,Department of Cancer Biology
[5] Vanderbilt University Medical Center,undefined
来源
Digestive Diseases and Sciences | 2010年 / 55卷
关键词
Esophageal; Cancer; Therapy; Surgery; Radiation; Targets;
D O I
暂无
中图分类号
学科分类号
摘要
Esophageal adenocarcinoma is an aggressive malignancy with a poor outcome, and its incidence continues to rise at an alarming rate. Current treatment strategies combining chemotherapy, radiation, and surgery are plagued with high rates of recurrence and metastasis. Multiple molecular pathways including the epidermal growth factor receptor, vascular endothelial growth factor, v-erb-b2 erythroblastic leukemia viral oncogene homolog (ERBB2), and Aurora kinase pathways are activated in many esophageal adenocarcinomas. In many cases, these pathways have critical roles in tumor progression. Research on the mechanisms by which these pathways contribute to disease progression has resulted in numerous biologic agents and small molecules with the potential to improve outcome. The promise of targeted therapy and personalized medicine in improving the clinical outcome is now closer than it has ever been.
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收藏
页码:3304 / 3314
页数:10
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