Loss of Heterozygosity on Chromosome 13q: Suggestion of a Candidate Tumor Suppressor Gene in Sporadic Breast Cancer

被引：0
|
作者：
Dan Tong
Eva Schuster
Klaus Czerwenka
Sepp Leodolter
Robert Zeillinger
机构：
[1] University of Vienna,Department of Obstetrics and Gynecology, Division of Gynecology
[2] University of Vienna,Department of Clinical Pathology
[3] University of Vienna,Ludwig
来源：
Breast Cancer Research and Treatment | 2004年 / 83卷
关键词：
LOH; 13q; sporadic breast cancer; tumor suppressor gene;
D O I：
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学科分类号：
摘要：
In order to corroborate the assumption that a candidate tumor suppressor gene is located on chromosome 13q21–22 between D13S1313 and D13S162, we examined loss of heterozygosity of six microsatellite markers in this region in 98 sporadic breast tumors. Our data demonstrate that loss of heterozygosity at 13q21–22 is not solely caused by genetic changes in BRCA2, but is also attributable to another gene in this region. There is strong indication of a new tumor suppressor gene located between D13S1313 and D13S162, most probably adjacent to D13S1308, which could play a role in sporadic breast cancer.
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页码：143 / 148
页数：5
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