The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards

被引：0
|
作者：
Christelle Baunez
Carine Dias
Martine Cador
Marianne Amalric
机构：
[1] Laboratoire de Neurobiologie de la Cognition,
[2] Unité Mixte de Recherche (UMR) 6155 Centre National de la Recherche Scientifique Université de Provence,undefined
[3] Laboratoire de Neuropsychobiologie des Désadaptations,undefined
[4] UMR5541 Centre National de la Recherche Scientifique,undefined
[5] Université de Bordeaux 2,undefined
来源：
Nature Neuroscience | 2005年 / 8卷
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摘要：
A challenge in treating drug addicts is preventing their pathological motivation for the drug without impairing their general affective state toward natural reinforcers. Here we have shown that discrete lesions of the subthalamic nucleus greatly decreased the motivation of rats for cocaine while increasing it for food reward. The subthalamic nucleus, a key structure controlling basal ganglia outputs, is therefore able to oppositely modulate the effect of 'natural' rewards and drugs of abuse on behavior. Modulating the activity of the subthalamic nucleus might prove to be a new target for the treatment of cocaine addiction.
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页码：484 / 489
页数：5
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