Role and therapeutic potential of Glycodelin A in systemic lupus erythematosus

被引：0
作者：
Hai-Feng Pan
Rui-Xue Leng
Ning Zhang
Jin-Hui Tao
Dong-Qing Ye
机构：
[1] Anhui Medical University,Department of Epidemiology and Biostatistics, School of Public Health
[2] Anhui Provincial Hospital,Department of Rheumatology
来源：
Rheumatology International | 2011年 / 31卷
关键词：
Glycodelin A; Systemic lupus erythematosus; Therapeutic target;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glycodelin A (GdA) is a lipocalin with an immunomodulatory role. Low expression of GdA has been implicated in the progression of autoimmune disease. Therefore, strategies targeting GdA may constitute an important target for the design of drugs for autoimmune disease including systemic lupus erythematosus (SLE). This opinion article will focus on current understanding of the role of GdA in the physiological and pathological functions associated with SLE. It is the intention of the article to provide insights that may assist in the development of GdA-based approaches for the treatment of SLE.
引用
收藏
页码：563 / 565
页数：2
相关论文
共 28 条
[1]  
Pan HF(2008)Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus Nat Clin Pract Rheumatol 4 352-353
[2]  
Ye DQ(2001)Sex differences in autoimmune disease Nat Immunol 2 777-780
[3]  
Li XP(2008)The B cell in systemic lupus erythaematosus: a rational target for more effective therapy Ann Rheum Dis 67 1374-1381
[4]  
Whitacre CC(2006)B cells move to centre stage: novel opportunities for autoimmune disease treatment Nat Rev Drug Discov 5 564-576
[5]  
Driver CB(2008)B-cell-targeted therapy for systemic lupus erythematosus: an update BioDrugs 22 239-249
[6]  
Ishimori M(2008)Glycodelin A induces a tolerogenic phenotype in monocyte-derived dendritic cells in vitro Am J Reprod Immunol 60 501-512
[7]  
Weisman MH(2005)Glycodelin A and differentiation of first trimester trophoblast cells in vitro Arch Gynecol Obstet 272 151-159
[8]  
Browning JL(2009)Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells Int J Biochem Cell Biol 41 1138-1147
[9]  
Ding C(2007)Differential sialylation regulates the apoptotic activity of glycodelin A FEBS Lett 581 4366-4370
[10]  
Foote S(2002)Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling J Exp Med 195 1199-1205
123