The effect of combined therapy with ritodrine, erythromycin and verapamil on the frequency of micronuclei in peripheral blood lymphocytes of pregnant women
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作者:
D. Grujičić
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机构:Faculty of Science,
D. Grujičić
O. Milošević Djordjević
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机构:Faculty of Science,
O. Milošević Djordjević
S. Arsenijević
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机构:Faculty of Science,
S. Arsenijević
D. Marinković
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机构:Faculty of Science,
D. Marinković
机构:
[1] Faculty of Science,
[2] University of Kragujevac,undefined
[3] Institute of Biology,undefined
[4] Department of Genetics,undefined
[5] Clinic of Gynecology,undefined
[6] Serbian Academy of Sciences and Arts,undefined
The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28±5.33. The frequency of micronuclei (MN) was estimated in peripheral blood lymphocytes of patients before surgical intervention and after the end of applied pharmacotherapy by application of cytokinesis block micronucleus (CBMN) test. Mean value of baseline MN frequency was 6.84±2.91 MN/1000 binucleated cells, and after the end of the applied therapy, 10.32±4.27 MN/1000 binucleated cells (P<0.001) were found. The data of cell proliferation index showed that the combined therapy did not induce significant difference in cell kinetics (P>0.05). Our results showed that combined pharmacotherapy treatment over six days significantly increased the frequency of MN in peripheral blood lymphocytes of pregnant women.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Raut Y.S.
Bhartiya U.S.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Bhartiya U.S.
Kand P.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
P. D. Hinduja National Hospital and Medical Research Centre, Mahim, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Kand P.
Hawaldar R.W.
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Tata Memorial Centre, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Hawaldar R.W.
Asopa R.V.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Asopa R.V.
Joseph L.J.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
Joseph L.J.
Rajan M.G.R.
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Radiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, MumbaiRadiation Medicine Centre, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai
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Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India
Joseph, Lebana J.
Bhartiya, Uma S.
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Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India
Bhartiya, Uma S.
Raut, Yogita S.
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Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India
Raut, Yogita S.
Kand, Purushottam
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Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India
Kand, Purushottam
Hawaidar, Rohini W.
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Tata Mem Hosp, Clin Res Secretariat, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India
Hawaidar, Rohini W.
Nair, Narendra
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Tata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, IndiaTata Mem Hosp Annexe, Radiat Med Ctr, Biomed Grp, Bhabha Atom Res Ctr, Bombay 400012, Maharashtra, India