Proteasome subunit Rpn13 is a novel ubiquitin receptor

被引:0
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作者
Koraljka Husnjak
Suzanne Elsasser
Naixia Zhang
Xiang Chen
Leah Randles
Yuan Shi
Kay Hofmann
Kylie J. Walters
Daniel Finley
Ivan Dikic
机构
[1] Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes,Department of Cell Biology
[2] Goethe University,Department of Biochemistry
[3] Theodor-Stern-Kai 7,Department of Immunology
[4] D-60590 Frankfurt (Main),undefined
[5] Germany ,undefined
[6] Tumor Biology Program,undefined
[7] Mediterranean Institute for Life Sciences,undefined
[8] Mestrovicevo setaliste,undefined
[9] 21000 Split,undefined
[10] Croatia ,undefined
[11] Harvard Medical School,undefined
[12] 240 Longwood Avenue,undefined
[13] Boston,undefined
[14] Massachsuetts 02115,undefined
[15] USA,undefined
[16] Molecular Biology and Biophysics,undefined
[17] University of Minnesota,undefined
[18] Minneapolis,undefined
[19] Minnesota 55455,undefined
[20] USA,undefined
[21] Miltenyi Biotec GmbH,undefined
[22] Stoeckheimer Weg 1,undefined
[23] D-50829 Koeln,undefined
[24] Germany ,undefined
[25] Medical School University of Split,undefined
[26] Soltanska 2,undefined
[27] 21000 Split,undefined
[28] Croatia,undefined
来源
Nature | 2008年 / 453卷
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摘要
Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation in eukaryotes. Here we report the identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome. Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain, which binds K48-linked diubiquitin with an affinity of approximately 90 nM. Like proteasomal ubiquitin receptor Rpn10/S5a, Rpn13 also binds ubiquitin-like (UBL) domains of UBL-ubiquitin-associated (UBA) proteins. In yeast, a synthetic phenotype results when specific mutations of the ubiquitin binding sites of Rpn10 and Rpn13 are combined, indicating functional linkage between these ubiquitin receptors. Because Rpn13 is also the proteasomal receptor for Uch37, a deubiquitinating enzyme, our findings suggest a coupling of chain recognition and disassembly at the proteasome.
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页码:481 / 488
页数:7
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