Disposition of Drugs in Block Copolymer Micelle Delivery SystemsFrom Discovery to Recovery

被引:0
作者
Hamidreza Montazeri Aliabadi
Mostafa Shahin
Dion R. Brocks
Afsaneh Lavasanifar
机构
[1] University of Alberta,Faculty of Pharmacy and Pharmaceutical Sciences
来源
Clinical Pharmacokinetics | 2008年 / 47卷
关键词
Paclitaxel; Pluronic; Maximum Tolerable Dose; Polymeric Micelle; Critical Micellar Concentration;
D O I
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中图分类号
学科分类号
摘要
Since their discovery in the early 1980s, polymeric micelles have been the subject of several studies as delivery systems that can potentially improve the therapeutic performance and modify the toxicity profile of encapsulated drugs by changing their pharmacokinetic characteristics. The efforts in this area have led in recent years to the advancement of several polymeric micellar formulations to clinical trials, some of which have shown promise in changing the biodistribution of the incorporated drug after intravenous administration as a means of tumour-targeted drug delivery. Recently, the possible benefit of polymeric micellar delivery in enhancing the absorption and bioavailability of incorporated drugs from alternative routes of drug administration has attracted interest. This article provides an overview of the effect of polymeric micellar delivery on absorption, distribution, metabolism and excretion of incorporated therapeutic agents. It also aims to assess the current information on the performance of polymeric micellar delivery systems in modifying the pharmacokinetics/pharmacodynamics of the incorporated drugs in clinical trials, and to re-examine the important structural factors required for successful design of polymeric micellar delivery systems capable of inducing favourable changes in the pharmacokinetics of the encapsulated drug.
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页码:619 / 634
页数:15
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