Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021

被引：0

作者：

Anna-Lisa Sorg

Leon Bergfeld

Marietta Jank

Victor Corman

Ilia Semmler

Anna Goertz

Andreas Beyerlein

Eva Verjans

Norbert Wagner

Horst Von Bernuth

Fabian Lander

Katharina Weil

Markus Hufnagel

Ute Spiekerkoetter

Cho-Ming Chao

Lutz Naehrlich

Ania Carolina Muntau

Ulf Schulze-Sturm

Gesine Hansen

Martin Wetzke

Anna-Maria Jung

Tim Niehues

Susanne Fricke-Otto

Ulrich Von Both

Johannes Huebner

Uta Behrends

Johannes G. Liese

Christian Schwerk

Christian Drosten

Ruediger Von Kries

Horst Schroten

机构：

[1] Ludwig-Maximilians-University Munich,Institute of Social Paediatrics and Adolescent Medicine, Division of Paediatric Epidemiology

[2] University Children’s Hospital,Institute of Virology

[3] Eberhard Karls University,Department of Paediatrics, Medical Faculty

[4] Charité Universitätsmedizin Berlin,Department of Paediatric Respiratory Medicine, Immunology, and Critical Care Medicine

[5] Paediatric Infectious Diseases,Department of Paediatrics

[6] Department of Paediatrics,Department of General Paediatrics, Neonatology, and Paediatric Cardiology, Medical Faculty

[7] Medical Faculty Mannheim,Department of Paediatrics and Adolescent Medicine

[8] Heidelberg University,Centre for Paediatrics and Adolescent Medicine, Hannover Medical School

[9] University Hospital RWTH Aachen,Department of General Paediatrics, Neonatology, Children’s Hospital Medical Centre

[10] Charité Universitätsmedizin Berlin,Department of Paediatrics

[11] University Hospital,Dr von Hauner Children’s Hospital

[12] and Medical Faculty Carl Gustav Carus,Department of Paediatrics, Faculty of Medicine

[13] Technical University (TU) Dresden,undefined

[14] University Hospital,undefined

[15] Heinrich-Heine-University Düsseldorf,undefined

[16] University Medical Centre,undefined

[17] Medical Faculty,undefined

[18] University of Freiburg,undefined

[19] University Medical Centre Rostock,undefined

[20] Department of Paediatrics,undefined

[21] University of Rostock,undefined

[22] Universities of Giessen and Marburg Lung Centre,undefined

[23] German Centre of Lung Research,undefined

[24] Department of Paediatrics,undefined

[25] Justus-Liebig-University Giessen,undefined

[26] University Children’s Hospital,undefined

[27] University Medical Centre Hamburg- Eppendorf,undefined

[28] Excellence Cluster RESIST,undefined

[29] Deutsche Forschungsgemeinschaft (DFG),undefined

[30] Saarland University Hospital,undefined

[31] Helios Klinikum Krefeld,undefined

[32] University Hospital,undefined

[33] Ludwig-Maximilians-University,undefined

[34] Technical University Munich,undefined

[35] University Hospital of Wuerzburg,undefined

[36] Department of Paediatrics,undefined

[37] Division of Paediatric Infectious Diseases,undefined

来源：

Nature Communications | / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The rate of SARS-CoV-2 infections in children remains unclear due to many asymptomatic cases. We present a study of cross-sectional seroprevalence surveys of anti-SARS-CoV-2 IgG in 10,358 children recruited in paediatric hospitals across Germany from June 2020 to May 2021. Seropositivity increased from 2.0% (95% CI 1.6, 2.5) to 10.8% (95% CI 8.7, 12.9) in March 2021 with little change up to May 2021. Rates increased by migrant background (2.8%, 4.4% and 7.8% for no, one and two parents born outside Germany). Children under three were initially 3.6 (95% CI 2.3, 5.7) times more likely to be seropositive with levels equalising later. The ratio of seropositive cases per recalled infection decreased from 8.6 to 2.8. Since seropositivity exceeds the rate of recalled infections considerably, serologic testing may provide a more valid estimate of infections, which is required to assess both the spread and the risk for severe outcomes of SARS-CoV-2 infections.

引用

共 50 条

[41] SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study
Shields, Adrian
Faustini, Sian E.
Perez-Toledo, Marisol
Jossi, Sian
Aldera, Erin
Allen, Joel D.
Al-Taei, Saly
Backhouse, Claire
Bosworth, Andrew
Dunbar, Lyndsey A.
Ebanks, Daniel
Emmanuel, Beena
Garvey, Mark
Gray, Joanna
Kidd, I. Michael
McGinnell, Golaleh
McLoughlin, Dee E.
Morley, Gabriella
O'Neill, Joanna
Papakonstantinou, Danai
Pickles, Oliver
Poxon, Charlotte
Richter, Megan
Walker, Eloise M.
Wanigasooriya, Kasun
Watanabe, Yasunori
Whalley, Celina
Zielinska, Agnieszka E.
Crispin, Max
Wraith, David C.
Beggs, Andrew D.
Cunningham, Adam F.
Drayson, Mark T.
Richter, Alex G.
THORAX, 2020, 75 (12) : 1089 - 1094
[42] Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021
Jessica Beser
Ilias Galanis
Theresa Enkirch
Sharon Kühlmann Berenzon
Edward van Straten
Jan Duracz
Marie Rapp
Katherina Zakikhany
Mikael Mansjö
Julia Wigren Byström
Mattias N. E. Forsell
Ramona Groenheit
Karin Tegmark Wisell
Andreas Bråve
Scientific Reports, 12
[43] Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021
Beser, Jessica
Galanis, Ilias
Enkirch, Theresa
Berenzon, Sharon Kuhlmann
van Straten, Edward
Duracz, Jan
Rapp, Marie
Zakikhany, Katherina
Mansjo, Mikael
Bystrom, Julia Wigren
Forsell, Mattias N. E.
Groenheit, Ramona
Wisell, Karin Tegmark
Brave, Andreas
SCIENTIFIC REPORTS, 2022, 12 (01)
[44] Seroprevalence of SARS-CoV-2 antibodies among blood donors in Québec: an update from a serial cross-sectional study
Antoine Lewin
Gaston De Serres
Yves Grégoire
Josée Perreault
Mathieu Drouin
Marie-Josée Fournier
Tony Tremblay
Julie Beaudoin
Amélie Boivin
Guillaume Goyette
Andrés Finzi
Renée Bazin
Marc Germain
Gilles Delage
Christian Renaud
Canadian Journal of Public Health, 2022, 113 : 385 - 393
[45] Potential drawbacks of SARS-CoV-2 seroprevalence surveys
Lippi, G.
JOURNAL OF HOSPITAL INFECTION, 2021, 110 : 206 - 206
[46] Seroprevalence of SARS-CoV-2 antibodies among primary healthcare workers in the Republic of Srpska, Bosnia & Herzegovina: A cross-sectional study
Knezevic, Darija
Petkovic, Miroslav
Bozic, Ljiljana
Miljus, Natasa
Mijovic, Biljana
Acimovic, Jela
Djakovic-Devic, Jelena
Puhalo-Sladoje, Dragana
Masic, Srdjan
Spaic, Dragan
Todorovic, Nevena
Pilipovic-Broceta, Natasa
Petrovic, Verica
Bokonjic, Dejan
Stojiljkovic, Milos P.
Skrbic, Ranko
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2022, 69 (01) : 18 - 26
[47] Seroprevalence of SARS-CoV-2 virus antibodies and sociodemographic features of pregnant women in Mogadishu, Somalia: a cross-sectional survey study
Nur, Maryan Abdullahi Sh
Dahie, Hassan Abdullahi
Hassan, Nima Abdi
Garba, Bashiru
Adam, Mohamed Husein Adam
Mohamoud, Jamal Hassan
Dirie, Najib Isse
BMJ OPEN, 2022, 12 (06):
[48] SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021
Gallian, Pierre
Hoze, Nathanael
Brisbarre, Nadege
Villarroel, Paola Mariela Saba
Nurtop, Elif
Isnard, Christine
Pastorino, Boris
Richard, Pascale
Morel, Pascal
Cauchemez, Simon
de Lamballerie, Xavier
ISCIENCE, 2023, 26 (04)
[49] SARS-CoV-2 seroprevalence in children, parents and school personnel from June 2020 to April 2021: cohort study of 55 schools in Switzerland
Ulyte, Agne
Haile, Sarah R.
Blankenberger, Jacob
Radtke, Thomas
Puhan, Milo A.
Kriemler, Susi
SWISS MEDICAL WEEKLY, 2022, 152
[50] Evolution of SARS-CoV-2 seroprevalence and clusters in school children from June 2020 to April 2021: prospective cohort study Ciao Corona
Ulyte, Agne
Radtke, Thomas
Abela, Irene A.
Haile, Sarah R.
Ammann, Priska
Berger, Christoph
Trkola, Alexandra
Fehr, Jan
Puhan, Milo A.
Kriemler, Susi
SWISS MEDICAL WEEKLY, 2021, 151

← 1 2 3 4 5 →