Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021

被引：0

作者：

Anna-Lisa Sorg

Leon Bergfeld

Marietta Jank

Victor Corman

Ilia Semmler

Anna Goertz

Andreas Beyerlein

Eva Verjans

Norbert Wagner

Horst Von Bernuth

Fabian Lander

Katharina Weil

Markus Hufnagel

Ute Spiekerkoetter

Cho-Ming Chao

Lutz Naehrlich

Ania Carolina Muntau

Ulf Schulze-Sturm

Gesine Hansen

Martin Wetzke

Anna-Maria Jung

Tim Niehues

Susanne Fricke-Otto

Ulrich Von Both

Johannes Huebner

Uta Behrends

Johannes G. Liese

Christian Schwerk

Christian Drosten

Ruediger Von Kries

Horst Schroten

机构：

[1] Ludwig-Maximilians-University Munich,Institute of Social Paediatrics and Adolescent Medicine, Division of Paediatric Epidemiology

[2] University Children’s Hospital,Institute of Virology

[3] Eberhard Karls University,Department of Paediatrics, Medical Faculty

[4] Charité Universitätsmedizin Berlin,Department of Paediatric Respiratory Medicine, Immunology, and Critical Care Medicine

[5] Paediatric Infectious Diseases,Department of Paediatrics

[6] Department of Paediatrics,Department of General Paediatrics, Neonatology, and Paediatric Cardiology, Medical Faculty

[7] Medical Faculty Mannheim,Department of Paediatrics and Adolescent Medicine

[8] Heidelberg University,Centre for Paediatrics and Adolescent Medicine, Hannover Medical School

[9] University Hospital RWTH Aachen,Department of General Paediatrics, Neonatology, Children’s Hospital Medical Centre

[10] Charité Universitätsmedizin Berlin,Department of Paediatrics

[11] University Hospital,Dr von Hauner Children’s Hospital

[12] and Medical Faculty Carl Gustav Carus,Department of Paediatrics, Faculty of Medicine

[13] Technical University (TU) Dresden,undefined

[14] University Hospital,undefined

[15] Heinrich-Heine-University Düsseldorf,undefined

[16] University Medical Centre,undefined

[17] Medical Faculty,undefined

[18] University of Freiburg,undefined

[19] University Medical Centre Rostock,undefined

[20] Department of Paediatrics,undefined

[21] University of Rostock,undefined

[22] Universities of Giessen and Marburg Lung Centre,undefined

[23] German Centre of Lung Research,undefined

[24] Department of Paediatrics,undefined

[25] Justus-Liebig-University Giessen,undefined

[26] University Children’s Hospital,undefined

[27] University Medical Centre Hamburg- Eppendorf,undefined

[28] Excellence Cluster RESIST,undefined

[29] Deutsche Forschungsgemeinschaft (DFG),undefined

[30] Saarland University Hospital,undefined

[31] Helios Klinikum Krefeld,undefined

[32] University Hospital,undefined

[33] Ludwig-Maximilians-University,undefined

[34] Technical University Munich,undefined

[35] University Hospital of Wuerzburg,undefined

[36] Department of Paediatrics,undefined

[37] Division of Paediatric Infectious Diseases,undefined

来源：

Nature Communications | / 13卷

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摘要：

The rate of SARS-CoV-2 infections in children remains unclear due to many asymptomatic cases. We present a study of cross-sectional seroprevalence surveys of anti-SARS-CoV-2 IgG in 10,358 children recruited in paediatric hospitals across Germany from June 2020 to May 2021. Seropositivity increased from 2.0% (95% CI 1.6, 2.5) to 10.8% (95% CI 8.7, 12.9) in March 2021 with little change up to May 2021. Rates increased by migrant background (2.8%, 4.4% and 7.8% for no, one and two parents born outside Germany). Children under three were initially 3.6 (95% CI 2.3, 5.7) times more likely to be seropositive with levels equalising later. The ratio of seropositive cases per recalled infection decreased from 8.6 to 2.8. Since seropositivity exceeds the rate of recalled infections considerably, serologic testing may provide a more valid estimate of infections, which is required to assess both the spread and the risk for severe outcomes of SARS-CoV-2 infections.

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