Comparison of three methods for pharmacokinetic screening in rats using LC-MS-MS

被引：0
|
作者：
S. Briem
E. Eklund
G. Williams
J. Brunvoll
机构：
[1] Department of DMPK Research AstraZeneca R&D Södertälje,Micromass AB Sweden
[2] University of Tromsø,Institute of Pharmacy
[3] University of Tromsø,undefined
来源：
Chromatographia | 2002年 / 55卷
关键词：
Liquid chromatography-mass spectrometry; Sample preparation; Ian suppression; Pharmacokinetic screening;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The influence of sample preparation on ion suppression is studied using the model compounds ropivacaine and 3OH-ropivacaine. Three sample preparation techniques are assessed: Solid Phase Extraction (SPE), Direct Dilution and Protein Precipitation. Although requiring more method development and being more time-consuming than the two alternative preparation techiques, SPE had a greater impact on reducing ion suppression.
引用
收藏
页码：S35 / S39
相关论文
共 50 条
  • [21] Determination of Fulvestrant in Rat Plasma by LC-MS-MS: Application to a Pharmacokinetic Study
    Liu, Zhongyang
    Gu, Guangzhi
    Xia, Huimin
    Liu, Qiang
    Pang, Zhiqing
    Jiang, Xinguo
    Chen, Jun
    CHROMATOGRAPHIA, 2011, 74 (3-4) : 227 - 234
  • [22] LC-MS-MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study
    Cui, Xiangyong
    Zhang, Mengliang
    Guan, Xin
    Yin, Lei
    Sun, Yantong
    Fawcett, J. Paul
    Gu, Jingkai
    CHROMATOGRAPHIA, 2011, 73 (1-2) : 165 - 169
  • [23] Screening of rifamycin producing marine sponge bacteria by LC-MS-MS
    Hewavitharana, Amitha K.
    Shaw, P. Nicholas
    Kim, Tae Kyung
    Fuerst, John A.
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 852 (1-2): : 362 - 366
  • [24] Determination of glimepiride in human plasma by LC-MS-MS and comparison of sample preparation methods for glimepiride
    Kim, H
    Chang, KY
    Park, CH
    Jang, MS
    Lee, JA
    Lee, HJ
    Lee, KR
    CHROMATOGRAPHIA, 2004, 60 (1-2) : 93 - 98
  • [25] Screening for drugs of abuse in hair with ion spray LC-MS-MS
    Kronstrand, R
    Nyström, I
    Strandberg, J
    Druid, H
    FORENSIC SCIENCE INTERNATIONAL, 2004, 145 (2-3) : 183 - 190
  • [26] Highly Sensitive LC-MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats
    Sulochana, Suresh Ponnayyan
    Ravichandiran, Vishnuvardh
    Mullangi, Ramesh
    Sukumaran, Sathesh Kumar
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2016, 54 (03) : 397 - 404
  • [27] LC-MS-MS Determination and Pharmacokinetic Study of the Novel Anti-Tumor Candidate Drug TEOA in Rats
    Gu, Jifeng
    Ding, Guoqiang
    Chen, Nianzu
    Zhang, Zhen
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2013, 51 (06) : 496 - 501
  • [28] Determination of Glimepiride in Human Plasma by LC-MS-MS and Comparison of Sample Preparation Methods for Glimepiride
    Hohyun Kim
    Kyu Young Chang
    Chang Hun Park
    Moon Sun Jang
    Jung-Ae Lee
    Hee Joo Lee
    Kyung Ryul Lee
    Chromatographia, 2004, 60 : 93 - 98
  • [29] Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS
    He, Wen-Qing
    Lv, Wei-Sheng
    Zhang, Yu
    Qu, Zhao
    Wei, Ren-Rong
    Zhang, Lei
    Liu, Chang-Hui
    Zhou, Xin-Xin
    Li, Wei-Rong
    Huang, Xiao-Tao
    Wang, Qi
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2015, 53 (08) : 1265 - 1273
  • [30] Simultaneous determination of three aconitum alkaloids in urine by LC-MS-MS
    Wang, Zhaohong
    Wang, Zhiping
    Wen, Jiao
    He, Yi
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 45 (01) : 145 - 148
12345