Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

被引：15

作者：

Divyambika C.V. ^{[1
]}

Sathasivasubramanian S. ^{[1
]}

Vani G. ^{[2
]}

Vanishree A.J. ^{[2
]}

Malathi N. ^{[3
]}

机构：

[1] Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai

[2] Department of Biochemistry, University of Madras, Guindy Campus, Chennai

[3] Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai

来源：

Indian Journal of Clinical Biochemistry | 2018年 / 33卷 / 3期

关键词：

Fibrotic bands; Glutathione; Glutathione peroxidase; Mouth opening; Oral submucous fibrosis; Superoxide dismutase;

D O I：

10.1007/s12291-017-0689-7

中图分类号：

学科分类号：

摘要：

This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Unstimulated saliva from both control and OSF patients were analysed for oxidative markers like lipid peroxides (LPO), non-enzymic antioxidants [reduced glutathione (GSH), vitamin A, vitamin E, vitamin C] and enzymatic antioxidants [glutathione peroxidase (GPx), superoxide dismutase (SOD)] and correlated with different stages and grades. Total salivary protein and LPO were significantly increased in OSF group with no significant change in the levels of GSH compared to controls. In OSF patients, a significant decrease in the levels of vitamins A, C and E was observed. The activities of salivary SOD and GPx were significantly decreased in OSF patients compared to controls. These changes significantly correlated with the increasing and differing grades of OSF that reflects increased oxidative stress with the progress of OSF. © 2017, Association of Clinical Biochemists of India.

引用

页码：348 / 355

页数：7

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